Auer, Timo Alexander and Fischer, Thomas and Garcia, Stephan Rodrigo Marticorena and Penzkofer, Tobias and Jung, Ernst-Michael and Hamm, Bernd and Lerchbaumer, Markus Herbert (2020) Value of contrast-enhanced ultrasound (CEUS) in Focal Liver Lesions (FLL) with inconclusive findings on cross-sectional imaging. CLINICAL HEMORHEOLOGY AND MICROCIRCULATION, 74 (3). pp. 327-339. ISSN 1386-0291, 1875-8622
Full text not available from this repository. (Request a copy)Abstract
BACKGROUND: Contrast-enhanced ultrasound (CEUS) has been used as an additional imaging technique in order to evaluate focal liver lesions. CEUS is easy and fast to perform, overcomes the limitations of B-mode US. OBJECTIVE: To evaluate the diagnostic potential of contrast-enhanced ultrasound (CEUS) in focal liver lesions (FLL) with unclear findings on computed tomography (CT) or magnetic resonance imaging (MRI). METHODS: In this single-center retrospective study, 146 patients with at least one FLL underwent additional CEUS of the liver to clarify inconclusive cross-sectional imaging findings. Ultrasonography was performed using B-mode imaging and CEUS after injection of sulphur hexafluoride microbubbles (second-generation contrast agent) within two months after ceMRI or ceCT and interpreted by an experienced radiologist (EFSUMB level 3). Histopathological reports, long-term follow-up or clinical course served as reference standard. RESULTS: Thirty-eight of the 146 patients had malignant and 108 benign FLL. Overall, CEUS had 92% sensitivity (95%-CI, 79-97) and 98% specificity (95%-CI, 93-99) with an AUC of 0.95 in correctly characterizing the lesion as malignant or benign. Sensitivity increased to 98% (95%-CI, 96-100) for benign lesions and decreased to 92% (95%-CI, 78-98) for malignant lesions. CEUS showed the highest diagnostical accuracy in lesion <1 cm with an AUC of 1.000, while the lowest accuracy was achieved in lesions >2 cm with an AUC of 0.924 due to a decreasing specificity of 86% (95%-CI, 87-100). CONCLUSION: CEUS correctly distinguished malignant from benign FLL in cases with inconclusive cross-sectional imaging findings and achieved high levels of diagnostic accuracy. CEUS has added diagnostic value especially in small lesions <= 1 cm while specificity remains limited in larger lesions.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CLINICAL-PRACTICE RECOMMENDATIONS; HEPATOCELLULAR-CARCINOMA; NODULAR HYPERPLASIA; PROSPECTIVE MULTICENTER; DIAGNOSTIC PERFORMANCE; DIFFERENTIAL-DIAGNOSIS; PRACTICE GUIDELINES; MANAGEMENT; CIRRHOSIS; PATTERN; CEUS; focal liver lesions; sonography; contrast-enhanced ultrasound; liver ultrasound |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Röntgendiagnostik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 Apr 2021 08:21 |
| Last Modified: | 06 Apr 2021 08:21 |
| URI: | https://pred.uni-regensburg.de/id/eprint/45393 |
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