Poyet, Cedric and Hermanns, Thomas and Zhong, Qing and Drescher, Eva and Eberli, Daniel and Burger, Maximilian and Hofstaedter, Ferdinand and Hartmann, Arndt and Stoehr, Robert and Zwarthoff, Ellen C. and Sulser, Tullio and Wild, Peter J. (2015) Positive fibroblast growth factor receptor 3 immunoreactivity is associated with low-grade non-invasive urothelial bladder cancer. ONCOLOGY LETTERS, 10 (5). pp. 2753-2760. ISSN 1792-1074, 1792-1082
Full text not available from this repository. (Request a copy)Abstract
In addition to conventional clinicopathological parameters, molecular markers are also required in order to predict the course of disease in patients with urothelial bladder cancer(BC). Little is known about fibroblast growth factor receptor 3 (FGFR3) immunoreactivity and the clinical significance it may possess with regard to BC. The present study aimed to investigate the immunoreactivity of FGFR3 in primary urothelial bladder tumours, with regard to clinicopathological features and FGFR3 mutation status. Tissue microarrays were used to immunohistochemically analyse FGFR3 expression in 255 primary, unselected patients with BC. FGFR3 mutations were detected using SNaPshot analysis. Positive FGFR3 immunoreactivity was identified in 113/207 analysable cases (54.6%), and was significantly associated with FGFR3 mutation (P<0.001), low tumour stage (P<0.001), low histological grade (P<0.001) and a papillary growth pattern (P<0.001). Positive FGFR3 immunostaining (P=0.002) and FGFR3 mutation (P=0.002) were found to be significantly associated with increased disease-specific survival following univariate analysis, demonstrating a median follow-up period of 75 months. Using multivariate analyses, FGFR3 immunoreactivity was found not to be independent of classical pathological parameters. Immunohistochemical expression of FGFR3 is an early occurrence during the carcinogenesis of papillary non-invasive BC. The presence of FGFR3 immunoreactivity in non-invasive papillary urothelial carcinomas may be utilised as an indicator of tumours possessing low-grade features and good prognosis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FREQUENT FGFR3 MUTATIONS; PROTEIN EXPRESSION; CELL-CARCINOMA; STAGE-TA; STAINING PATTERN; TUMORS; PATHWAYS; DEFINE; P53; PREDICTION; fibroblast growth factor receptor 3 protein; urothelial cancer; molecular markers; grading; prognosis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 May 2019 13:03 |
| Last Modified: | 07 May 2019 13:03 |
| URI: | https://pred.uni-regensburg.de/id/eprint/4540 |
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