Lonic, Daniel and Heidekrueger, Paul and Bosselmann, Talia and Broer, P. Niclas and Gertler, Ralph and Martin, Klaus Wolfgang and Prantl, Lukas and Ninkovic, Milomir and Giunta, Riccardo and Ehrl, Denis (2020) Is major burn injury associated with coagulopathy? The value of thrombelastometry in the detection of coagulopathy in major burn injury: A prospective observational study. CLINICAL HEMORHEOLOGY AND MICROCIRCULATION, 76 (2). pp. 299-308. ISSN 1386-0291, 1875-8622
Full text not available from this repository. (Request a copy)Abstract
BACKGRUND: The coagulation status of burn patients is generally impaired and is a major factor of the deteriorating burn patients' overall situation. In trauma and other patient groups, the differential diagnosis of coagulation impairment has been largely improved by the use of rotational thromboelastometry (ROTEM (R)). The aim of this prospective observational study was the differentiated observation of coagulopathy in severely burned patients using standard parameters and ROTEM (R) thrombelastometry during the relevant stages of burn disease. PATIENTS AND METHODS: Twelve patients that sustained at least 20% third degree burns of total body surface area (TBSA) were included in the study. Standard and ROTEM (R) coagulation analyses were performed on admission and then twice daily during the first 14 days following burn trauma. RESULTS: Although the initial assessment of DIC was similar for both standard labs and ROTEM (R) measurements, more patients were detected to be in a state of worsening coagulation status for a longer time in ROTEM (R) than in standard measurements. In addition, one patient was rated in to be in decompensated DIC for 3 days according to ROTEM (R) measurements, while no patient was rated to be in a decompensated DIC based on standard parameters. CONCLUSION: This study points towards a more complex picture and higher occurrence of DIC in burn patients when thrombelastometric measurements like ROTEM (R) are taken into account in addition to standard coagulation parameters.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HYPERFIBRINOLYSIS; HEMOSTASIS; MANAGEMENT; POLYTRAUMA; DIAGNOSIS; CARE; Thrombelastometry; coagulation; burn injury |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Plastische-, Hand- und Wiederherstellungschirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 Apr 2021 09:02 |
| Last Modified: | 06 Apr 2021 09:02 |
| URI: | https://pred.uni-regensburg.de/id/eprint/45404 |
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