Krueger-Genge, A. and Jung, F. and Hufert, F. and Jung, E-M and Kupper, J-H and Storsberg, J. (2020) Effects of gut microbial metabolite trimethylamine N-oxide (TMAO) on platelets and endothelial cells. CLINICAL HEMORHEOLOGY AND MICROCIRCULATION, 76 (2). pp. 309-316. ISSN 1386-0291, 1875-8622
Full text not available from this repository. (Request a copy)Abstract
Thrombotic events result from different pathologies and are the underlying causes of severe diseases like stroke or myocardial infarction. Recent basic research now revealed a link between food uptake, food conversion and gut metabolism. Gut microbial production of trimethylamine N-oxide (TMAO) from dietary nutrients like choline, lecithin and L-carnitine was associated with the development of cardiovascular diseases. Within this review we give a systematic overview about the influence of TMAO on blood components like platelets and endothelial cells which both are involved as key players in thrombotic processes. In summary, a mechanistic correlation between the gut microbiome, TMAO and cardiovascular diseases becomes obvious and emphasizes to the significance of the intestinal microbiome.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | EPOXYEICOSATRIENOIC ACIDS; L-CARNITINE; DISEASE; HIV; PHOSPHATIDYLCHOLINE; HYPERREACTIVITY; DYSFUNCTION; EPOXYEICOSANOIDS; ATHEROSCLEROSIS; OUTCOMES; Microbiome; trimethylamin-N-oxide; platelets; endothelial cells; atherosclerosis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Röntgendiagnostik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 Apr 2021 09:04 |
| Last Modified: | 06 Apr 2021 09:04 |
| URI: | https://pred.uni-regensburg.de/id/eprint/45405 |
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