Strasser, Barbara and Kohlboeck, Gabriele and Hermanky, Maria and Leitzmann, Michael (2020) Role of dietary protein and exercise on biomarkers of immune activation in older patients during hospitalization. AGING CLINICAL AND EXPERIMENTAL RESEARCH, 32 (11). pp. 2419-2423. ISSN 1594-0667, 1720-8319
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The aim of this study was to examine the effect of short-term protein supplementation (aiming to consume 1.2 g protein/kg body weight per day) combined with moderate resistance training on 3 days of the week on tryptophan-kynurenine metabolism in 40 older patients with hip fracture. Secondary outcomes for physical recovery were hand-grip strength and chair-rise score. Older patients with hip fracture exhibited higher degrees of immune activation, detected by increased neopterin and kynurenine to tryptophan levels compared with reference values for healthy elderly with no significant differences between those who received the exercise-protein intervention compared to the control. Increasing dietary protein intake during hospitalization did not alleviate the Th1-type immune response in the elderly patient. On the other hand, muscularity per se may affect immune activation responses following injury, as improvements in maximum hand-grip strength with the intervention were related to decreases in neopterin levels.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INFLAMMATION; STRENGTH; Aging; Exercise; Dietary protein; Muscle disuse; Tryptophan-kynurenine metabolism |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 Apr 2021 11:01 |
| Last Modified: | 06 Apr 2021 11:01 |
| URI: | https://pred.uni-regensburg.de/id/eprint/45428 |
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