Holzer, Florian and Gruber, Michael and Philipp, Alois and Lunz, Dirk and Graf, Bernhard and Redel, Andreas (2020) Predictors of bleeding in ECMO patients undergoing surgery. MINERVA ANESTESIOLOGICA, 86 (1). pp. 47-55. ISSN 0375-9393, 1827-1596
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BACKGROUND: Bleeding is a major adverse effect of veno-venous extracorporeal membrane oxygenation (vvECMO) therapy in surgical patients. This study retrospectively describes the amount of transfused packed red blood cells (PRBC) and coagulation parameters of patients requiring surgery during vvECMO therapy. METHODS: We included patients who underwent at least one surgical procedure during vvECMO therapy and analyzed hemoglobin levels, coagulation parameters, blood gas parameters and transfused blood products. Patients with perioperative transfusion of less than two PRBC during the perioperative period (group A) were compared to those who were given two or more PRBCs (group B). RESULTS: Seventy-three patients (group A: 42 patients, group B: 31 patients) were included. Activated via (54.7 vs. 56.2 sec), Quick test (61.5% vs. 60.0%), Platelet count (91 vs 72/nL, P=0.322) and mortality (40.5 vs. 45.2%; P=0.689) were not different between both groups. Fibrinogen was significantly decreased in group B (245 mg/dL) compared to group A (353 mg/dL; P=0.004). CONCLUSIONS: In patients requiring surgery during vvECMO therapy with perioperative transfusion of two or more PRBCs preoperative fibrinogen levels were significantly reduced compared to patients with transfusion of less than two PRBCs. No other analyzed lab value showed any predictive qualities in terms of bleeding.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | EXTRACORPOREAL MEMBRANE-OXYGENATION; RESPIRATORY-DISTRESS-SYNDROME; COAGULATION MANAGEMENT; CLINICAL-PRACTICE; HEPARIN; TRANSFUSION; ANTICOAGULATION; TIME; Extracorporeal membrane oxygenation; Hemorrhage; Blood transfusion; Blood coagulation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie Medicine > Lehrstuhl für Herz-, Thorax- und herznahe Gefäßchirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Apr 2021 06:37 |
| Last Modified: | 07 Apr 2021 06:37 |
| URI: | https://pred.uni-regensburg.de/id/eprint/45476 |
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