Marschall, Manfred and Strojan, Hanife and Kiener, Richard and Wangen, Christina and Sonntag, Eric and Mueller, Regina and Zeittraeger, Isabel and Wagner, Sabrina and Stamminger, Thomas and Milbradt, Jens and Behrends, Uta and Koerber, Nina and Bauer, Tanja and Schroedel, Silke and Thirion, Christian and Wagner, Ralf and Hutterer, Corina (2020) Differential upregulation of host cell protein kinases by the replication of alpha-,beta- and gamma-herpesviruses provides a signature o virus-specific signalling. JOURNAL OF GENERAL VIROLOGY, 101 (3). pp. 284-289. ISSN 0022-1317, 1465-2099
Full text not available from this repository. (Request a copy)Abstract
Infections with human herpesviruses share several molecular characteristics, but the diversified medical outcomes are distinct to viral subfamilies and species. Notably, both clinical and molecular correlates of infection are a challenging field and distinct patterns of virus-host interaction have rarely been defined: this study therefore focuses on the search for virus-specific molecular indicators. As previous studies have demonstrated the impact of herpesvirus infections on changes in host signalling path- ways, we illustrate virus-modulated expression levels of individual cellular protein kinases. Current data reveal (i) alpha- and beta-, gamma-herpesvirus-specific patterns of kinase modulation as well as (ii) differential levels of up-/downregulated kinase expression and phosphorylation, which collectively suggest (iii) defined signalling patterns specific for the various viruses (VSS) that may prove useful for defining molecular indicators. Combined, the study confirms the correlation between herpesviral replication and modulation of signalling kinases, possibly exploitable for the in vitro characterization of viral infections.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CYTOMEGALOVIRUS; PUL97; PATHOGENESIS; KINOME; PUL69; PP65; herpesviral replication; primary human fibroblasts; modulation of the host kinome; differential upregulation of cellular kinases; signature of virus-specific signalling |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Apr 2021 08:52 |
| Last Modified: | 07 Apr 2021 08:52 |
| URI: | https://pred.uni-regensburg.de/id/eprint/45492 |
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