Kjolbaek, Louise and Benitez-Paez, Alfonso and Gomez del Pulgar, Eva M. and Brahe, Lena K. and Liebisch, Gerhard and Matysik, Silke and Rampelli, Simone and Vermeiren, Joan and Brigidi, Patrizia and Larsen, Lesli H. and Astrup, Arne and Sanz, Yolanda (2020) Arabinoxylan oligosaccharides and polyunsaturated fatty acid effects on gut microbiota and metabolic markers in overweight individuals with signs of metabolic syndrome: A randomized cross-over trial. CLINICAL NUTRITION, 39 (1). pp. 67-79. ISSN 0261-5614, 1532-1983
Full text not available from this repository. (Request a copy)Abstract
Background & aims: Gut microbiota composition is linked to obesity and metabolic syndrome. The nutrients and doses required to modulate the gut microbiota towards beneficially influence components of the metabolic syndrome are unclear. This study aimed to investigate diet-induced effects on the gut microbiota and metabolic markers in overweight individuals with indices of the metabolic syndrome. Methods: A twelve-week randomized cross-over trial was conducted with two intervention periods separated by a washout period. The dietary intakes of interest were wheat bran extract, rich in arabinoxylan oligosaccharides (AXOS) (10.4 g/d AXOS) and polyunsaturated fatty acids (PUFA) (3.6 g/d n-3 PUFA). Dietary records, fecal and blood samples, as well as anthropometric data, were collected before and after intervention. Anthropometry and gastrointestinal symptoms were evaluated weekly. Gut microbiota composition was analyzed by massive sequencing of 16S ribosomal RNA gene V3-V4 amplicons. Results: Twenty-seven participants completed the study (90%). Intake of AXOS induced an expected bifidogenic effect on gut microbiota (p < 0.01) and increased butyrate-producing bacterial species as well (p < 0.05). Beta-diversity analysis indicated that the structure of the gut microbiota only changed as a result of the AXOS intervention (Permanova = 1.90, p < 0.02) and no changes in metabolic markers were observed after any of the interventions. Conclusions: AXOS intake has a bifidogenic effect and also increases butyrate producers in the gut microbiota; even though this type of dietary fiber did not modulate lipid or glucose metabolic parameters related to metabolic syndrome. Four-week PUFA intake did not induce any notable effect on the gut microbiota composition or metabolic risk markers. (C) 2019 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | WHEAT BRAN EXTRACT; INTESTINAL MICROBIOTA; REFINED WHEAT; WHOLE-GRAIN; GLUCOSE; OMEGA-3-FATTY-ACIDS; FERMENTATION; SENSITIVITY; CONSUMPTION; METAGENOME; Gut microbiota; Arabinoxylan oligosaccharide; Fiber; Fish oil; Metabolic syndrome; Obesity |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Apr 2021 11:36 |
| Last Modified: | 07 Apr 2021 11:36 |
| URI: | https://pred.uni-regensburg.de/id/eprint/45503 |
Actions (login required)
 |
View Item |
