Rau, Beate and Brandl, Andreas and Piso, Pompiliu and Pelz, Joerg and Busch, Peter and Demtroeder, Cedric and Schuele, Silke and Schlitt, Hans-Juergen and Roitman, Marc and Tepel, Juergen and Sulkowski, Udo and Uzunoglu, Faik and Huenerbein, Michael and Hoerbelt, Ruediger and Stroehlein, Michael and Beckert, Stefan and Koenigsrainer, Ingmar and Koenigsrainer, Alfred (2020) Peritoneal metastasis in gastric cancer: results from the German database. GASTRIC CANCER, 23 (1). pp. 11-22. ISSN 1436-3291, 1436-3305
Full text not available from this repository. (Request a copy)Abstract
Background Patients with peritoneal metastases of gastric cancer have a poor prognosis with a median survival of 7 months. A benefit of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) could be shown in several selected patient cohorts but remains controversial. The aim of this study was, to reflect the results of a national German HIPEC registry initiated by the German Society of General and Visceral Surgery (DGAV). Methods The DGAV HIPEC registry StuDoQ|Peritoneum documents patients with peritoneal malignancy contributed from 52 hospitals. All consecutive documented patients from 2011 until 2016 (n = 3078) were treated with CRS and HIPEC and were analysed. A total of 315 (10%) suffered from gastric cancer and were analysed. Results A complete data set of 235 patients was available for this study, including 113 male (48.1%) and 122 female (51.9%) patients with a median age of 53.4 years (SD +/- 11.9). The median PCI was 8.0 (range 1-30). A complete cytoreduction was achieved in 121 patients (71.6%). Postoperative complications (Clavien-Dindo grades 3-4) occurred in 40 patients (17%). The median overall survival (OS) time was 13 months. The 5-year survival rate was 6%. According to the PCI from 0-6 (n = 74); 7-15 (n = 70) and 16-39 (n = 24) the median OS differs significantly (18 months vs. 12 months vs. 5 months; p = 0.002). Conclusions CRS and HIPEC in selected patients with gastric cancer and peritoneal spread can improve survival when they are treated in centers. An accurate staging and patient selection are of major importance to achieve long-term survival.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HYPERTHERMIC INTRAPERITONEAL CHEMOTHERAPY; CYTOREDUCTIVE SURGERY; PERIOPERATIVE INTRAPERITONEAL; HISTOPATHOLOGICAL REGRESSION; SURGICAL-TREATMENT; CARCINOMATOSIS; METAANALYSIS; GASTRECTOMY; DOCETAXEL; SURVIVAL; Peritoneal metastases; Gastric cancer; Cytoreductive surgery; Hyperthermic intraperitoneal chemotherapy |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 Apr 2021 06:30 |
| Last Modified: | 08 Apr 2021 06:30 |
| URI: | https://pred.uni-regensburg.de/id/eprint/45511 |
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