van Bragt, Job J. M. H. and Adcock, Ian M. and Bel, Elisabeth H. D. and Braunstahl, Gert-Jan and ten Brinke, Anneke and Busby, John and Canonica, Giorgio W. and Cao, Hui and Chung, Kian Fan and Csoma, Zsuzsanna and Dahlen, Barbro and Davin, Elizabeth and Hansen, Susanne and Heffler, Enrico and Horvath, Ildiko and Korn, Stephanie and Kots, Maxim and Kuna, Piotr and Kwon, Namhee and Louis, Renaud and Plaza, Vicente and Porsbjerg, Celeste and Ramos-Barbon, David and Richards, Levi B. and Skrgat, Sabina and Sont, Jacob K. and Vijverberg, Susanne J. H. and Weersink, Els J. M. and Yasinska, Valentyna and Wagers, Scott S. and Djukanovic, Ratko and Maitland-van der Zee, Anke H. and Abenhardt, B. and Adcock, I. M. and Adler, J. and Alfonso, R. and Ali, R. and Alkameh, S. and Almonacid Sanchez, C. and Alvares, L. and Anderson, G. and Assing, K. and Ayre, S. and Becker, J. and Bel, E. H. D. and Bergmann, K. and Bieksiene, K. and Bjerring, N. and Blasi, F. and Bloemen, P. and Blum, H. and Boeing, S. and Bonavia, M. and Bossios, A. and Bourdin, A. and Braunstahl, G-J and Brons, A. and Brusselle, G. and Buis, J. and Busby, J. and Caiaffa, M. and Calabrese, C. and Camiciottoli, G. and Canonica, G. W. and Cao, H. and Caruso, C. and Castilla Martinez, M. and Centanni, S. and Chung, K. F. and Cisneros Serrano, C. and Corsico, A. and Cosmi, L. and Costantino, M. and Costello, R. and Crimi, N. and Csoma, Z. and Dahlen, S. and Dahlen, B. and D'Amato, M. and Davies, D. and Davin, E. and Garcia-Cosio Piqueras, F. de Borja and Decarlo, G. and Deimling, A. and Del Giacco, S. and Diaz Campos, R. and Djandji, M. and Djukanovic, R. and Doberer, D. and Dupont, L. and Dyett, K. and Edelbaher, N. and Edelmann, M. and Ehmann, R. and Ekberg-Jansson, A. and Farsi, A. and Favero, E. and Feimer, J. and Fletcher, M. and Foschino, B. and Frankemolle, B. and Gaga, M. and Gappa, M. and Garcia de Pedro, J. and Garcia Rivero, J. and Gasplmayr, M. and Gebhardt, R. and Geldmacher, H. and Geltner, C. and Gerstlauer, M. and Gibson, T. and Giuseppe, G. and Gogoll, C. and Grimm-Sachs, V and Grisle, I and Gruen, B. and Gruenewaldt, A. and Guarnieri, G. and Gullon Blanco, J. and Hamelmann, E. and Hamerlijnck, D. and Hammers-Reinhard, A. and Hanon, S. and Hansen, S. and Harzheim, D. and Heaney, L. and Heffler, E. and Hellmich, S. and Herden, M. and Hering, T. and Herth, F. and Hilberg, O. and Horvath, I and Howarth, P. and Hubatsch, M. and Humbert, M. and Husemann, K. and Idzko, M. and Jackson, D. and Jandl, M. and Jaumont, X. and Joos, G. and Joest, M. and Juech, M. and Kabesch, M. and Kaiser-Labusch, P. and Kardos, P. and Kaessner, F. and Keeley, T. and Kerr, W. and Kirschner, J. and Klimek, L. and Koca, M. and Koczulla, R. and Koerner-Rettberg, C. and Kopac, P. and Korn, S. and Kots, M. and Kronsbein, J. and Kuna, P. and Lipinska, I. Kuprys and Kwon, N. and Langer, M. and Langeveld, B. and Lantz, A. and Lazarinis, N. and Lazic, Z. and Lehtimaki, L. and Leuppi, J. and Lombardi, C. and Lommatzsch, M. and Lopez-Vina, A. and Louis, R. and Luca, R. and Ludviksdottir, D. and Luettecke-Hecht, C. and Macchia, L. and Magni, T. and Maitland-van der Zee, A. H. and Martinez Rivera, C. and Mastoridis, P. and Mazza, F. and Menzella, F. and Menzies-Gow, A. and Michils, A. and Mihaltan, F. and Milanese, M. and Milger-Kneidinger, K. and Molinska, J. and Montagna, I and Montuschi, P. and Muelleneisen, N. and Munoz Esquerre, M. and Nanzer-Kelly, A. and Nenasheva, N. and Neurohr, C. and Nucera, E. and Otker, J. and Oud, K. and Paggiaro, P. and Parente, R. and Parkinson, J. and Passalacqua, G. and Patberg, N. and Patella, V and Patino, O. and Paulsson, T. and Peche, R. and Pelaia, G. and Peress, E. and Perez de Llano, L. and Pfeffer, P. and Pfister, P. and Pilette, C. and Pinedo Sierra, C. and Pini, L. and Plaza, V and Porsbjerg, C. and Powitz, F. and Ramos-Barbon, D. and Ranger, T. and Rasmussen, L. and Rasmussen, K. and Rezelj, M. and Ricciardi, L. and Ricciardolo, F. and Richards, L. B. and Ridolo, E. and Rijssenbeek-Nouwens, L. and Rolla, G. and Romero Ribate, D. and Ruediger, S. and Safioti, G. and Sandstrom, T. and Santus, P. and Sauer, R. and Schauerte, G. and Schipmann, R. and Schleich, F. and Schmid, J. and Schmidt, F. and Schmidt, O. and Schmitz, M. and Schrag, T. and Schroeer, S. and Schultz, K. and Schulz, C. and Scichilone, N. and Sedlak, V and Selb, J. and Senna, G. and Sergejeva, S. and Serrano Pariente, J. and Sichau, M. and Simona, D. and Singer, A. and Skowasch, D. and Skrgat, S. and Smeenk, F. and Smith, S. and Solidoro, P. and Sont, J. K. and Spadaro, G. and Spanevello, A. and Stefansdottir, M. and Steinmetz, K. and Steiss, J. and Stephan, M. and Stieglitz, S. and Suhling, H. and Taube, C. and ten Brinke, A. and Yavuz, S. Tolga and Tudoric, N. and Ulrik, C. and van Bragt, J. J. M. H. and van de Ven, M. and van den Elshout, F. and Van Dyke, M. and Van Nederveen-Bendien, S. and van Veen, I and Vandenplas, O. and Velthove, K. and Vianello, A. and Vijverberg, S. J. H. and Vogelberg, C. and Wagers, S. S. and Wallen-Nielsen, E. and Weersink, E. J. and Wisskirchen, T. and Yacoub, M. and Yancey, S. and Yasinska, V and Zappa, M. and Zielen, S. and Zimmermann, C. and Zimmermann, R. (2020) Characteristics and treatment regimens across ERS SHARP severe asthma registries. EUROPEAN RESPIRATORY JOURNAL, 55 (1): 1901163. ISSN 0903-1936, 1399-3003
Full text not available from this repository. (Request a copy)Abstract
Little is known about the characteristics and treatments of patients with severe asthma across Europe, but both are likely to vary. This is the first study in the European Respiratory Society Severe Heterogeneous Asthma Research collaboration, Patient-centred (SHARP) Clinical Research Collaboration and it is designed to explore these variations. Therefore, we aimed to compare characteristics of patients in European severe asthma registries and treatments before starting biologicals. This was a cross-sectional retrospective analysis of aggregated data from 11 national severe asthma registries that joined SHARP with established patient databases. Analysis of data from 3236 patients showed many differences in characteristics and lifestyle factors. Current smokers ranged from 0% (Poland and Sweden) to 9.5% (Belgium), mean body mass index ranged from 26.2 (Italy) to 30.6 kg.m(-2) (the UK) and the largest difference in mean pre-bronchodilator forced expiratory volume in 1 s % predicted was 20.9% (the Netherlands versus Hungary). Before starting biologicals patients were treated differently between countries: mean inhaled corticosteroid dose ranged from 700 to 1335 mu g.day(-1) between those from Slovenia versus Poland when starting anti-interleukin (IL)5 antibody and from 772 to 1344 mu g.day(-1) in those starting anti-IgE (Slovenia versus Spain). Maintenance oral corticosteroid use ranged from 21.0% (Belgium) to 63.0% (Sweden) and from 9.1% (Denmark) to 56.1% (the UK) in patients starting anti-IL-5 and anti-IgE, respectively. The severe asthmatic population in Europe is heterogeneous and differs in both clinical characteristics and treatment, often appearing not to comply with the current European Respiratory Society/American Thoracic Society guidelines definition of severe asthma. Treatment regimens before starting biologicals were different from inclusion criteria in clinical trials and varied between countries.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HETEROGENEITY; MULTICENTER; MEPOLIZUMAB; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 Apr 2021 06:43 |
| Last Modified: | 08 Apr 2021 06:43 |
| URI: | https://pred.uni-regensburg.de/id/eprint/45516 |
Actions (login required)
 |
View Item |
