Schaible, Jan and Utpatel, Kirsten and Verloh, Niklas and Einspieler, Ingo and Pregler, Benedikt and Zeman, Florian and Wiggermann, Philipp and Schreyers, Andreas G. and Stroszczynski, Christian and Beyer, Lukas P. (2020) Full-Core Biopsy Systems Take Larger Liver Tissue Samples with Lower Fragmentation Rates Than Conventional Side-Notch Systems: A Randomized Trial. CANCER MANAGEMENT AND RESEARCH, 12. pp. 1121-1128. ISSN 1179-1322,
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Background: The aim of this study was to compare the histopathological quality and physical features of the specimen of a full-core end-cut biopsy system with that of the standard side-notch system for liver biopsies. Methods: A full-core end-cut 16G biopsy device and a standard side-notch 16G needle were used to take biopsies of unclear liver lesions. Patients were randomized in two groups of 16 patients each. The primary endpoint of this prospective study was the core length measured using a dedicated microscope imaging software. Secondary endpoints were the quality of the specimen rated by an independent pathologist unaware of the device (scale from 1 to 5; with 1 as best and 5 as worst), the core diameter (determined by the microscopic imaging software) and presence of fragmentation (evaluated by the pathologist). Results: For the full-core (FC) and side-notch (SN) groups, the mean core length was similar with 13,599 mu m and 11,570 mu m (p=0.131), respectively. The quality of the specimen was significantly better in the FC-group with an average rating of 1.68 vs 2.50 (p=0.009). The fragmentation rate in the FC-group was statistically significantly lower at 2/27 (7%) than in the SN-group at 13/33 (39%) (p=0.021). The diameter in the FC-group was 1042 mu m vs 930 mu m in SN-group (p=0.018).
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PERCUTANEOUS NEEDLE-BIOPSY; liver biopsy; full-core; side-notch; liver tumor; biopsy system |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie Medicine > Lehrstuhl für Röntgendiagnostik Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Klinische Studien |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 Apr 2021 06:46 |
| Last Modified: | 08 Apr 2021 06:46 |
| URI: | https://pred.uni-regensburg.de/id/eprint/45519 |
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