Renner, Kerstin and Schwittay, Tobias and Chaabane, Sophia and Gottschling, Johanna and Mueller, Christine and Tiefenboeck, Charlotte and Salewski, Jan-Niklas and Winter, Frederike and Buchtler, Simone and Balam, Saidou and Malfertheiner, Maximilian V. and Lubnow, Matthias and Lunz, Dirk and Graf, Bernhard and Hitzenbichler, Florian and Hanses, Frank and Poeck, Hendrik and Kreutz, Marina and Orso, Evelyn and Burkhardt, Ralph and Niedermair, Tanja and Brochhausen, Christoph and Gessner, Andre and Salzberger, Bernd and Mack, Matthias (2021) Severe T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes. NATURE COMMUNICATIONS, 12 (1): 3006. ISSN 2041-1723
Full text not available from this repository. (Request a copy)Abstract
Coronavirus disease 2019 (COVID-19) can lead to pneumonia and hyperinflammation. Here we show a sensitive method to measure polyclonal T cell activation by downstream effects on responder cells like basophils, plasmacytoid dendritic cells, monocytes and neutrophils in whole blood. We report a clear T cell hyporeactivity in hospitalized COVID-19 patients that is pronounced in ventilated patients, associated with prolonged virus persistence and reversible with clinical recovery. COVID-19-induced T cell hyporeactivity is T cell extrinsic and caused by plasma components, independent of occasional immunosuppressive medication of the patients. Monocytes respond stronger in males than females and IL-2 partially restores T cell activation. Downstream markers of T cell hyporeactivity are also visible in fresh blood samples of ventilated patients. Based on our data we developed a score to predict fatal outcomes and identify patients that may benefit from strategies to overcome T cell hyporeactivity. Perturbed T cell responses and disturbed cytokine secretion have been shown during SARS-CoV2 infection in patients. Here the authors show reduced polyclonal T cell activity in COVID-19 patients that is caused by plasma factors and linked to poor prognosis and viral persistence.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DISEASE; IL-3 |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) Medicine > Lehrstuhl für Innere Medizin II Medicine > Abteilung für Nephrologie Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene Medicine > Lehrstuhl für Pathologie Medicine > Zentren des Universitätsklinikums Regensburg > Regensburger Centrum für Interventionelle Immunologie (RCI) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Jun 2022 06:19 |
| Last Modified: | 01 Jun 2022 06:19 |
| URI: | https://pred.uni-regensburg.de/id/eprint/45569 |
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