Buder, Felix and Bauswein, Markus and Magnus, Clara L. and Audebert, Franz and Lang, Henriette and Kundel, Christof and Distler, Karin and Reuschel, Edith and Lubnow, Matthias and Mueller, Thomas and Lunz, Dirk and Graf, Bernhard and Schmid, Stephan and Mueller, Martina and Poeck, Hendrik and Hanses, Frank and Salzberger, Bernd and Peterhoff, David and Wenzel, Jurgen J. and Schmidt, Barbara and Lampl, Benedikt M. J. (2022) Contribution of High Viral Loads, Detection of Viral Antigen and Seroconversion to Severe Acute Respiratory Syndrome Coronavirus 2 Infectivity. JOURNAL OF INFECTIOUS DISEASES, 225 (2). pp. 190-198. ISSN 0022-1899, 1537-6613
Full text not available from this repository. (Request a copy)Abstract
Background. From a public health perspective, effective containment strategies for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) should be balanced with individual liberties. Methods. We collected 79 respiratory samples from 59 patients monitored in an outpatient center or in the intensive care unit of the University Hospital Regensburg. We analyzed viral load by quantitative real-time polymerase chain reaction, viral antigen by point-of-care assay, time since onset of symptoms, and the presence of SARS-CoV-2 immunoglobulin G (IgG) antibodies in the context of virus isolation from respiratory specimens. Results. The odds ratio for virus isolation increased 1.9-fold for each log(10) level of SARS-CoV-2 RNA and 7.4-fold with detection of viral antigen, while it decreased 6.3-fold beyond 10 days of symptoms and 20.0-fold with the presence of SARS-CoV-2 antibodies. The latter was confirmed for B.1.1.7 strains. The positive predictive value for virus isolation was 60.0% for viral loads > 10(7) RNA copies/mL and 50.0% for the presence of viral antigen. Symptom onset before 10 days and seroconversion predicted lack of infectivity with negative predictive values of 93.8% and 96.0%. Conclusions. Our data support quarantining patients with high viral load and detection of viral antigen and lifting restrictive measures with increasing time to symptom onset and seroconversion. Delay of antibody formation may prolong infectivity.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SARS-COV-2; SARS-CoV-2; infectivity; viral load; viral antigen; seroconversion; public health |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Geburtshilfe) Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) Medicine > Lehrstuhl für Innere Medizin II Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene Medicine > Zentren des Universitätsklinikums Regensburg > Rettungszentrum Regensburg e.V. |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 Jul 2022 09:33 |
| Last Modified: | 05 Jul 2022 09:33 |
| URI: | https://pred.uni-regensburg.de/id/eprint/45596 |
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