Spanier, Gerrit and Ugele, Ines and Nieberle, Felix and Symeou, Luisa and Schmidhofer, Sandra and Brand, Almut and Meier, Johannes and Spoerl, Steffen and Krupar, Rosemarie and Rummele, Petra and Siska, Peter and Renner, Kathrin and Peter, Katrin and Gerken, Michael and Beckhove, Philipp and Reichert, Torsten E. and Kreutz, Marina and Singer, Katrin (2021) The predictive power of CD3(+) T cell infiltration of oral squamous cell tumors is limited to non-diabetic patients. CANCER LETTERS, 499. pp. 209-219. ISSN 0304-3835, 1872-7980
Full text not available from this repository. (Request a copy)Abstract
Diabetes mellitus type II (DM) and immune cell infiltration determine patient outcome in many tumor entities. Here we studied a possible link between the metabolic and immune cell status of OSCC patients. Glucose transporter (GLUT) 1 mRNA expression was elevated in all tumor samples, whereas other glycolytic markers such as lactate dehydrogenase (LDH) A or monocarboxylate transporter (MCT) 1 were increased in tumor samples from patients with diabetes and these patients had a significantly worse prognosis compared to non-diabetic patients. Analyses of immune cell infiltration in tumors from diabetic and non-diabetic patients revealed an increased leukocyte (CD45(+)) infiltration compared to normal mucosa only in non-diabetic patients. In line, the amount of CD3(+) T cells per mm(2) tumor tissue, was elevated in patients without diabetes and crucial for patient outcome in OSCC patients without diabetes, as compared to healthy mucosa using fluorescence immunohistochemistry in tissue microarrays of 229 patients. Our results demonstrate that diabetes is a prognostic factor for OSCC patients and associates with decreased leukocyte and CD3(+) infiltration indicating that metabolic differences between diabetic and non-diabetic patients may alter tumor-infiltrating T cells and thereby determine patient outcome.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NECK-CANCER; POOR-PROGNOSIS; HEAD; SURVIVAL; GLUCOSE; RISK; METABOLISM; LACTATE; EPIDEMIOLOGY; EXPRESSION; OSCC; Diabetes mellitus; TIL; Metabolism; Prognosis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Hals-Nasen-Ohren-Heilkunde Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) Medicine > Lehrstuhl für Mund-, Kiefer- und Gesichtschirurgie Medicine > Lehrstuhl für Pathologie Medicine > Zentren des Universitätsklinikums Regensburg > eHealth Competence Center Medicine > Zentren des Universitätsklinikums Regensburg > Regensburger Centrum für Interventionelle Immunologie (RCI) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 Jul 2022 10:23 |
| Last Modified: | 05 Jul 2022 10:23 |
| URI: | https://pred.uni-regensburg.de/id/eprint/45602 |
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