Driendl, Sarah and Arzt, Michael and Zimmermann, Claudia S. and Jung, Bettina and Pukrop, Tobias and Boeger, Carsten A. and Haferkamp, Sebastian and Zeman, Florian and Heid, Iris M. and Stadler, Stefan (2021) Sleep apnoea and incident malignancy in type 2 diabetes. ERJ OPEN RESEARCH, 7 (2): 00036-2021. ISSN , 2312-0541
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Background: Sleep apnoea and type 2 diabetes (T2D) have been linked to malignancy. The aim of the present study was to evaluate the association between sleep apnoea and incidence of malignancy in patients with T2D. Methods: The DIACORE (DIAbetes COhoRtE) study is a prospective, population-based cohort study in T2D patients. In the sleep disordered breathing substudy, the apnoea-hypopnoea index (AHI), oxygen desaturation index (ODI) and percentage of night-time spent with a peripheral oxygen saturation of <90% (t(sat90%)) were assessed using a two-channel ambulatory monitoring device. Malignancy diagnoses were gathered using self-reported medical history data validated by medical records. Hazard ratios (HRs) for incident malignancy were derived by Cox regression adjusting for sex, age, body mass index, smoking status, alcohol intake, socioeconomic status and HbA1c. Results: Of 1239 patients with T2D (mean age 67 years, 41% female, mean body mass index 30.9 kg.m(-2)), 79 (6.4%) were first-time diagnosed with a malignancy within a median follow-up period of 2.7 years (interquartile range 2.2-4.5 years). AHI, ODI and tsat90% were not associated with incident malignancy. In subgroup analysis, females showed increased cancer risk per AHI unit (adjusted HR 1.03 per AHI unit, 95% CI 1.00-1.06; p=0.028) and severe sleep apnoea (defined as AHI >= 30 events.h(-1); adjusted HR 4.19, 95% CI 1.39-12.77; p=0.012). This was not seen in males, and a significant interaction was observed (interaction terms p=0.048 and p=0.033, respectively). Conclusion: Sleep apnoea was not associated with incident malignancy in T2D patients. However, stratified analysis revealed a significant association between sleep apnoea and incident malignancy in females, but not in males.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HEALTH-CARE UTILIZATION; INTERMITTENT HYPOXIA; CANCER INCIDENCE; GENDER-DIFFERENCES; MOUSE MODEL; PREVALENCE; ASSOCIATION; PROGRESSION; APNEALINK(TM); ANGIOGENESIS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) Medicine > Lehrstuhl für Innere Medizin II Medicine > Abteilung für Nephrologie Medicine > Institut für Epidemiologie und Präventivmedizin > Lehrstuhl für Genetische Epidemiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 Jul 2022 14:16 |
| Last Modified: | 05 Jul 2022 14:16 |
| URI: | https://pred.uni-regensburg.de/id/eprint/45607 |
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