Lubnow, Matthias and Schmidt, Barbara and Fleck, Martin and Salzberger, Bernd and Mueller, Thomas and Peschel, Georg and Schneckenpointner, Roland and Lange, Tobias and Hitzenbichler, Florian and Kieninger, Martin and Lunz, Dirk and Graf, Bernhard and Brochhausen, Christoph and Weber, Florian and Lueke, Florian and Peterhoff, David and Schuster, Philipp and Hiergeist, Andreas and Offner, Robert and Hehr, Ute and Wallner, Stefan and Hanses, Frank and Schmid, Stephan and Weigand, Kilian and Geismann, Florian and Poeck, Hendrik and Pukrop, Tobias and Evert, Matthias and Gessner, Andre and Burkhardt, Ralph and Herr, Wolfgang and Maier, Lars S. and Heudobler, Daniel (2021) Secondary hemophagocytic lymphohistiocytosis and severe liver injury induced by hepatic SARS-CoV-2 infection unmasking Wilson's disease: Balancing immunosuppression. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 103. pp. 624-627. ISSN 1201-9712, 1878-3511
Full text not available from this repository. (Request a copy)Abstract
A 21-year-old woman was hospitalized due to coronavirus disease 2019 (COVID-19)-associated respiratory and hepatic impairment concomitant with severe hemolytic anemia. Upon diagnosis of secondary hemophagocytic lymphohistiocytosis, immunosuppression with anakinra and steroids was started, leading to a hepatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and viremia. Subsequent liver biopsy revealed virus particles in hepatocytes by electron microscopy and SARS-CoV-2 virus could be isolated and cultured. Immunosuppression was stopped and convalescent donor plasma given. In the differential diagnosis, an acute crisis of Wilson's disease was raised by laboratory and genetic testing. This case highlights the complexity of balancing immunosuppression to control hyperinflammation versus systemic SARS-CoV-2 dissemination. (C) 2021 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | COVID-19; SARS-CoV-2; COVID-19; Liver injury; Hemophagocytic lymphohistiocytosis; Wilson's disease |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie Medicine > Lehrstuhl für Humangenetik Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) Medicine > Lehrstuhl für Innere Medizin II Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene Medicine > Lehrstuhl für Pathologie Medicine > Zentren des Universitätsklinikums Regensburg > Rettungszentrum Regensburg e.V. |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 Jul 2022 05:34 |
| Last Modified: | 06 Jul 2022 05:34 |
| URI: | https://pred.uni-regensburg.de/id/eprint/45612 |
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