Glueck, Vivian and Grobecker, Sonja and Koestler, Josef and Tydykov, Leonid and Bertok, Manuela and Weidlich, Tanja and Gottwald, Christine and Salzberger, Bernd and Wagner, Ralf and Zeman, Florian and Koller, Michael and Gessner, Andre and Schmidt, Barbara and Glueck, Thomas and Peterhoff, David (2022) Immunity after COVID-19 and vaccination: follow-up study over 1 year among medical personnel. INFECTION, 50 (2). pp. 439-446. ISSN 0300-8126, 1439-0973
Full text not available from this repository. (Request a copy)Abstract
Background The long-term course of immunity among individuals with a history of COVID-19, in particular among those who received a booster vaccination, has not been well defined so far. Methods SARS-CoV-2-specific antibody levels were measured by ELISA over 1 year among 136 health care workers infected during the first COVID-19 wave and in a subgroup after booster vaccination approximately 1 year later. Furthermore, spike-protein-reactive memory T cells were quantified approximately 7 months after the infection and after booster vaccination. Thirty healthy individuals without history of COVID-19 who were routinely vaccinated served as controls. Results Levels of SARS-CoV-2-specific IgM- and IgA-antibodies showed a rapid decay over time, whereas IgG-antibody levels decreased more slowly. Among individuals with history of COVID-19, booster vaccination induced very high IgG- and to a lesser degree IgA-antibodies. Antibody levels were significantly higher after booster vaccination than after recovery from COVID-19. After vaccination with a two-dose schedule, healthy control subjects developed similar antibody levels as compared to individuals with history of COVID-19 and booster vaccination. SARS-CoV-2-specific memory T cell counts did not correlate with antibody levels. None of the study participants suffered from a reinfection. Conclusions Booster vaccination induces high antibody levels in individuals with a history of COVID-19 that exceeds by far levels observed after recovery. SARS-CoV-2-specific antibody levels of similar magnitude were achieved in healthy, COVID-19-naive individuals after routine two-dose vaccination.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SARS-COV-2; COVID-19; SARS-CoV-2; Cellular immunity; Antibody-mediated immunity; SARS-CoV-2-vaccination |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Klinische Studien |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 Jul 2022 06:03 |
| Last Modified: | 06 Jul 2022 06:03 |
| URI: | https://pred.uni-regensburg.de/id/eprint/45626 |
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