Glueck, Vivian and Grobecker, Sonja and Tydykov, Leonid and Salzberger, Bernd and Glueck, Thomas and Weidlich, Tanja and Bertok, Manuela and Gottwald, Christine and Wenzel, Juergen J. and Gessner, Andre and Schmidt, Barbara and Peterhoff, David (2021) SARS-CoV-2-directed antibodies persist for more than six months in a cohort with mild to moderate COVID-19. INFECTION, 49 (4). pp. 739-746. ISSN 0300-8126, 1439-0973
Full text not available from this repository. (Request a copy)Abstract
Objective To follow serological immune responses of front-line healthcare workers after PCR-confirmed COVID-19 for a mean of 30 weeks, describe the time-course of SARS-CoV-2 spike protein-specific IgG, IgA and IgM levels and to identify associations of the immune response with symptoms, demographic parameters and severity of disease. Methods Anti-SARS-CoV-2 S protein-specific IgG, IgA and IgM antibodies were measured at three time points during the 30-week follow-up. COVID-19-specific symptoms were assessed with standardized questionnaires. Results 95% of the participants mounted an IgG response with only modest decline after week 12. IgG-type antibodies were still detectable in almost 90% of the subjects at 30 weeks. IgA and IgM responses were less robust and antibody titers decreased more rapidly. At 30 weeks, only 25% still had detectable IgA-type and none had IgM-type antibodies. Higher age and higher disease severity were independently associated with higher IgG antibody levels, albeit with wide variations. Conclusion Serological immune responses after COVID-19 show considerable inter-individual variability, but show an association with increasing age and higher severity of disease. IgG-type anti-SARS-CoV-2 antibodies remain positive in 90% of the individuals 30 weeks after onset of symptoms.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INFECTION; SARS-CoV-2; COVID-19; Serological immune response; Antibody titer; ELISA; Severity of disease |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 06 Jul 2022 09:24 |
| Last Modified: | 06 Jul 2022 09:24 |
| URI: | https://pred.uni-regensburg.de/id/eprint/45671 |
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