Schrimpf, Marlene and Liegl, Gregor and Boeckle, Markus and Leitner, Anton and Geisler, Peter and Pieh, Christoph (2015) The effect of sleep deprivation on pain perception in healthy subjects: a meta-analysis. SLEEP MEDICINE, 16 (11). pp. 1313-1320. ISSN 1389-9457, 1878-5506
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Background: There is strong evidence indicating an interaction between sleep and pain. However, the size of this effect, as well as the clinical relevance, is unclear. Therefore, this meta-analysis was conducted to quantify the effect of sleep deprivation on pain perception. Methods: A systematic literature search was conducted using the electronic databases PubMed, Cochrane, Psyndex, Psycinfo, and Scopus. By conducting a random-effect model, the pooled standardized mean differences (SMDs) of sleep deprivation on pain perception was calculated. Studies that investigated any kind of sleep deprivation in conjunction with a pain measurement were included. In cases of several pain measurements within a study, the average effect size of all measures was calculated. Results: Five eligible studies (N = 190) for the between-group analysis and ten studies (N = 266) for the within-group analysis were identified. Sleep deprivation showed a medium effect in the between-group analysis (SMD = 0.62; CI95: 0.12, 1.12; z = 2.43; p = 0.015) and a large effect in the within-group analysis (SMD = 1.49; CI95: 0.82, 2.17; z = 4.35; p < 0.0001). The test for heterogeneity was not significant in the between-group analysis (Q = 5.29; df = 4; p = 0.2584), but it was significant in the within-group analysis (Q = 53.49; df = 9; p < 0.0001). Conclusion: This meta-analysis confirms a medium effect (SMD = 0.62) of sleep deprivation on pain perception. As this meta-analysis is based on experimental studies in healthy subjects, the clinical relevance should be clarified. (C) 2015 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LOW-BACK-PAIN; DIABETIC PERIPHERAL NEUROPATHY; PLACEBO-CONTROLLED TRIAL; SELF-REPORTED SLEEP; QUALITY-OF-LIFE; DOUBLE-BLIND; REM-SLEEP; RHEUMATOID-ARTHRITIS; MUSCULOSKELETAL PAIN; CLINICAL-TRIALS; Sleep deprivation; Pain perception; Meta-analysis; Reciprocal relation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Psychosomatische Medizin Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 May 2019 07:28 |
| Last Modified: | 08 May 2019 07:28 |
| URI: | https://pred.uni-regensburg.de/id/eprint/4569 |
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