Pec, Jan and Wester, Michael and Fisser, Christoph and Debl, Kurt and Hamer, Okka W. and Poschenrieder, Florian and Buchner, Stefan and Maier, Lars S. and Arzt, Michael and Wagner, Stefan (2021) Central Sleep Apnea Is Associated with an Abnormal P-Wave Terminal Force in Lead V-1 in Patients with Acute Myocardial Infarction Independent from Ventricular Function. JOURNAL OF CLINICAL MEDICINE, 10 (23): 5555. ISSN , 2077-0383
Full text not available from this repository. (Request a copy)Abstract
Sleep-disordered breathing (SDB) is highly prevalent in patients with cardiovascular disease. We have recently shown that an elevation of the electrocardiographic (ECG) parameter P wave terminal force in lead V-1 (PTFV1) is linked to atrial proarrhythmic activity by stimulation of reactive oxygen species (ROS)-dependent pathways. Since SDB leads to increased ROS generation, we aimed to investigate the relationship between SDB-related hypoxia and PTFV1 in patients with first-time acute myocardial infarction (AMI). We examined 56 patients with first-time AMI. PTFV1 was analyzed in 12-lead ECGs and defined as abnormal when >= 4000 mu V*ms. Polysomnography (PSG) to assess SDB was performed within 3-5 days after AMI. SDB was defined by an apnea-hypopnea-index (AHI) >15/h. The multivariable regression analysis showed a significant association between SDB-related hypoxia and the magnitude of PTFV1 independent from other relevant clinical co-factors. Interestingly, this association was mainly driven by central but not obstructive apnea events. Additionally, abnormal PTFV1 was associated with SDB severity (as measured by AHI, B 21.495; CI [10.872 to 32.118]; p < 0.001), suggesting that ECG may help identify patients suitable for SDB screening. Hypoxia as a consequence of central sleep apnea may result in atrial electrical remodeling measured by abnormal PTFV1 in patients with first-time AMI independent of ventricular function. The PTFV1 may be used as a clinical marker for increased SDB risk in cardiovascular patients.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ATRIAL-FIBRILLATION; CARDIOVASCULAR EVENTS; CRYPTOGENIC STROKE; HEART-FAILURE; PREVALENCE; CARDIOPATHY; PREVENTION; OUTCOMES; CAMKII; IMPACT; acute myocardial infarction; p wave terminal force; central sleep apnea; sleep-disordered breathing |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Röntgendiagnostik Medicine > Universitäres Herzzentrum Regensburg (UHR) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 12 Jul 2022 05:45 |
| Last Modified: | 19 Jul 2022 06:23 |
| URI: | https://pred.uni-regensburg.de/id/eprint/45698 |
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