Pausch, Antonia-Maria and Kammerer, Sylvia and Weber, Florian and Herr, Wolfgang and Stroszczynski, Christian and Holler, Ernst and Edinger, Matthias and Wolff, Daniel and Weber, Daniela and Jung, Ernst-Michael and Wertheimer, Tobias (2021) Parametric Imaging of Contrast-Enhanced Ultrasound (CEUS) for the Evaluation of Acute Gastrointestinal Graft-Versus-Host Disease. CELLS, 10 (5): 1092. ISSN , 2073-4409
Full text not available from this repository. (Request a copy)Abstract
In recent years contrast-enhanced ultrasound (CEUS) has been an emerging diagnostic modality for the detection of acute gastrointestinal (GI) graft-versus-host disease (GvHD) in patients after allogeneic stem cell transplantation. However, broad clinical usage has been partially limited by its high dependence on the expertise of an experienced examiner. Thus, the aim of this study was to facilitate detection of acute GI GvHD by implementing false color-coded parametric imaging of CEUS. As such, two inexperienced examiners with basic knowledge in abdominal and vascular ultrasound analyzed parametric images obtained from patients with clinical suspicion for acute GvHD in a blinded fashion. As diagnostic gold standard, histopathological GvHD severity score on intestinal biopsies obtained from lower GI tract endoscopy was performed. The evaluation of parametric images by the two inexperienced ultrasound examiners in patients with histological confirmation of acute GI GvHD was successful in 17 out of 19 patients (89%) as opposed to analysis of combined B-mode ultrasound, strain elastography, and CEUS by an experienced examiner, which was successful in 18 out of 19 of the patients (95%). Therefore, CEUS with parametric imaging of the intestine was technically feasible and has the potential to become a valuable diagnostic tool for rapid and widely accessible detection of acute GvHD in clinical practice.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ACUTE GVHD; TRANSPLANTATION; DIAGNOSIS; CRITERIA; MARROW; GvHD; CEUS; parametric imaging; allogeneic stem cell transplantation; dynamic vascularization |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) Medicine > Lehrstuhl für Pathologie Medicine > Lehrstuhl für Röntgendiagnostik Medicine > Zentren des Universitätsklinikums Regensburg > Regensburger Centrum für Interventionelle Immunologie (RCI) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 12 Jul 2022 08:24 |
| Last Modified: | 12 Jul 2022 08:24 |
| URI: | https://pred.uni-regensburg.de/id/eprint/45728 |
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