Brunner, Stefan M. and Brennfleck, Frank W. and Junger, Henrik and Grosse, Jirka and Knoppke, Birgit and Geissler, Edward K. and Melter, Michael and Schlitt, Hans J. (2021) Successful auxiliary two-staged partial resection liver transplantation (ASPIRE-LTx) for end-stage liver disease to avoid small-for-size situations. BMC SURGERY, 21 (1): 166. ISSN , 1471-2482
Full text not available from this repository. (Request a copy)Abstract
Background Risks for living-liver donors are lower in case of a left liver donation, however, due to lower graft volume, the risk for small-for-size situations in the recipients increases. This study aims to prevent small-for-size situations in recipients using an auxiliary two-staged partial resection liver transplantation (LTX) of living-donated left liver lobes. Case presentation Two patients received a two-stage auxiliary LTX using living-donated left liver lobes after left lateral liver resection. The native extended right liver was removed in a second operation after sufficient hypertrophy of the left liver graft had occurred. Neither donor developed postoperative complications. In both recipients, the graft volume increased by an average of 105% (329 ml to 641 ml), from a graft-to-body-weight ratio of 0.54 to 1.08 within 11 days after LTX, so that the remnant native right liver could be removed. No recipient developed small-for-size syndrome; graft function and overall condition is good in both recipients after a follow-up time of 25 months. Conclusions Auxiliary two-staged partial resection LTX using living-donor left lobes is technically feasible and can prevent small-for-size situation. This new technique can expand the potential living-donor pool and contributes to increase donor safety.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ; Left liver living donation; Split liver transplantation; Auxiliary liver transplantation; ASPIRE |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie Medicine > Lehrstuhl für Kinder- und Jugendmedizin Medicine > Abteilung für Nuklearmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 19 Jul 2022 06:41 |
| Last Modified: | 19 Jul 2022 06:41 |
| URI: | https://pred.uni-regensburg.de/id/eprint/45753 |
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