Hitzenbichler, Florian and Bauernfeind, Stilla and Salzberger, Bernd and Schmidt, Barbara and Wenzel, Juergen J. (2021) Comparison of Throat Washings, Nasopharyngeal Swabs and Oropharyngeal Swabs for Detection of SARS-CoV-2. VIRUSES-BASEL, 13 (4): 653. ISSN , 1999-4915
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Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) RNA is detected by reverse-transcription quantitative real-time PCR (RT-qPCR) from respiratory specimens. This study compares throat washings (TW), nasopharyngeal swabs (NS) and oropharyngeal swabs (OS). A total of 102 samples from 34 adult patients with confirmed SARS-CoV-2 infection were analysed by RT-qPCR with absolute quantification. The median concentrations and diagnostic sensitivities were 5.8x10(4) copies/mL, 85% (NS), 1.4x10(4), 79% (OS) and 4.3x10(3), 85% (TW). Concentration differences were significant between NS and TW (P = 0.019). Saliva (SA) was available from 21 patients (median 3.4x10(3)). OS and TW can be considered for SARS-CoV-2 diagnostics, although with slightly lower concentrations.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ; SARS-CoV-2; COVID-19; throat washing; nasopharyngeal swab; oropharyngeal swab; saliva; nucleic acid test; PCR; RT-qPCR; diagnostic sensitivity |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 19 Jul 2022 09:16 |
| Last Modified: | 19 Jul 2022 09:16 |
| URI: | https://pred.uni-regensburg.de/id/eprint/45837 |
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