The Effect of Gender and Sex Hormones on Cardiovascular Disease, Heart Failure, Diabetes, and Atrial Fibrillation in Sleep Apnea

Hegner, Philipp and Lebek, Simon and Maier, Lars Siegfried and Arzt, Michael and Wagner, Stefan (2021) The Effect of Gender and Sex Hormones on Cardiovascular Disease, Heart Failure, Diabetes, and Atrial Fibrillation in Sleep Apnea. FRONTIERS IN PHYSIOLOGY, 12: 741896. ISSN 1664-042X

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Abstract

Sleep apnea is a highly prevalent disorder with increasing impact on healthcare systems worldwide. Previous studies have been conducted primarily with male subjects, and prevalence and severity of sleep apnea in women are underestimated. Recent clinical and basic science evidence increasingly points to different mechanisms in men and women with sleep-disordered breathing (SDB). SDB is associated with a variety of comorbidities, including cardiovascular disease, heart failure, diabetes, and atrial fibrillation. In this review, we discuss sex-dependent mechanisms of SDB in select associated conditions to sharpen our clinical understanding of these sex-dependent inherent differences.

Item Type: Article
Uncontrolled Keywords: ANTIOXIDANT ENZYME EXPRESSION; RETICULUM CA2+ LEAK; CLINICAL PRESENTATION; RISK-FACTORS; PREVALENCE; IMPACT; ESTROGEN; ASSOCIATION; PROTEIN; CAMKII; sleep apnea; sleep-disordered breathing; gender; atrial fibrillation; heart failure; cardiovascular disease; diabetes
Subjects: 600 Technology > 610 Medical sciences Medicine
Divisions: Medicine > Lehrstuhl für Innere Medizin II
Depositing User: Petra Gürster
Date Deposited: 16 Dec 2022 11:03
Last Modified: 16 Dec 2022 11:03
URI: https://pred.uni-regensburg.de/id/eprint/45852

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