Evert, Katja and Dienemann, Thomas and Brochhausen, Christoph and Lunz, Dirk and Lubnow, Matthias and Ritzka, Markus and Keil, Felix and Trummer, Matthias and Scheiter, Alexander and Salzberger, Bernd and Reischl, Udo and Boor, Peter and Gessner, Andre and Jantsch, Jonathan and Calvisi, Diego F. and Evert, Matthias and Schmidt, Barbara and Simon, Michaela (2021) Autopsy findings after long-term treatment of COVID-19 patients with microbiological correlation. VIRCHOWS ARCHIV, 479 (1). pp. 97-108. ISSN 0945-6317, 1432-2307
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Between April and June 2020, i.e., during the first wave of pandemic coronavirus disease 2019 (COVID-19), 55 patients underwent long-term treatment in the intensive care unit at the University Hospital of Regensburg. Most of them were transferred from smaller hospitals, often due to the need for an extracorporeal membrane oxygenation system. Autopsy was performed in 8/17 COVID-19-proven patients after long-term treatment (mean: 33.6 days). Autopsy revealed that the typical pathological changes occurring during the early stages of the disease (e.g., thrombosis, endothelitis, capillaritis) are less prevalent at this stage, while severe diffuse alveolar damage and especially coinfection with different fungal species were the most conspicuous finding. In addition, signs of macrophage activation syndrome was detected in 7 of 8 patients. Thus, fungal infections were a leading cause of death in our cohort of severely ill patients and may alter clinical management of patients, particularly in long-term periods of treatment.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ; COVID-19; Autopsy; Fungal infection; Mycosis; Macrophage activation syndrome |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie Medicine > Lehrstuhl für Chirurgie Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Innere Medizin II Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 19 Jul 2022 09:57 |
| Last Modified: | 19 Jul 2022 09:57 |
| URI: | https://pred.uni-regensburg.de/id/eprint/45861 |
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