Fisser, Christoph and Colling, Stefan and Debl, Kurt and Hetzenecker, Andrea and Sterz, Ulrich and Hamer, Okka W. and Fellner, Claudia and Maier, Lars S. and Buchner, Stefan and Arzt, Michael (2021) The impact of epicardial adipose tissue in patients with acute myocardial infarction. CLINICAL RESEARCH IN CARDIOLOGY, 110 (10). pp. 1637-1646. ISSN 1861-0684, 1861-0692
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Aims Epicardial adipose tissue (EAT) has been linked to impaired reperfusion success after percutaneous coronary intervention (PCI). Whether EAT predicts myocardial damage in the early phase after acute myocardial infarction (MI) is unclear. Therefore, we investigated whether EAT in patients with acute MI is associated with more microvascular obstruction (MVO), greater ST-deviation, larger infarct size and reduced myocardial salvage index (MSI). Methods and results This retrospective analysis of a prospective observational study including patients with acute MI (n = 54) undergoing PCI and 12 healthy matched controls. EAT, infarct size and MSI were analyzed with cardiac magnetic resonance imaging, conducted 3-5 days and 12 weeks after MI. Patients with acute MI showed higher EAT volume than healthy controls (46 [25.;75. percentile: 37;59] vs. 24 [15;29] ml, p < 0.001). The high EAT group (above median) showed significantly more MVO (2.22 [0.00;5.38] vs. 0.0 [0.00;2.18] %, p = 0.004), greater ST-deviation (0.38 [0.22;0.55] vs. 0.15 [0.03;0.20] mVx10(-1), p = 0.008), larger infarct size at 12 weeks (23 [17;29] vs. 10 [4;16] %, p < 0.001) and lower MSI (40 [37;54] vs. 66 [49;88] %, p < 0.001) after PCI than the low EAT group. After accounting for demographic characteristics, body-mass index, heart volume, infarct location, TIMI-flow grade as well as apnea-hypopnea index, EAT was associated with infarct size at 12 weeks (B = 0.38 [0.11;0.64], p = 0.006), but not with MSI. Conclusions Patients with acute MI showed higher volume of EAT than healthy individuals. High EAT was linked to more MVO and greater ST-deviation. EAT was associated with infarct size, but not with MSI. GRAPHICS.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CARDIOVASCULAR MAGNETIC-RESONANCE; PERCUTANEOUS CORONARY INTERVENTION; DISTURBED CARDIAC REPOLARIZATION; ST-SEGMENT RESOLUTION; MICROVASCULAR OBSTRUCTION; PROGNOSTIC VALUE; LEVEL ANALYSIS; FAT THICKNESS; SIZE; ASSOCIATION; Epicardial adipose tissue; Acute myocardial infarction; Microvascular obstruction; ST-deviation; Infarct size; Myocardial salvage index |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) Medicine > Lehrstuhl für Innere Medizin II Medicine > Lehrstuhl für Röntgendiagnostik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 19 Jul 2022 11:52 |
| Last Modified: | 19 Jul 2022 11:52 |
| URI: | https://pred.uni-regensburg.de/id/eprint/45869 |
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