Rosengarth, Katharina and Pai, Delin and Dodoo-Schittko, Frank and Hense, Katharina and Tamm, Teele and Ott, Christian and Luerding, Ralf and Bumes, Elisabeth and Greenlee, Mark W. and Schebesch, Karl Michael and Schmidt, Nils Ole and Doenitz, Christian (2021) A Novel Language Paradigm for Intraoperative Language Mapping: Feasibility and Evaluation. JOURNAL OF CLINICAL MEDICINE, 10 (4): 655. ISSN , 2077-0383
Full text not available from this repository. (Request a copy)Abstract
(1) Background-Mapping language using direct cortical stimulation (DCS) during an awake craniotomy is difficult without using more than one language paradigm that particularly follows the demand of DCS by not exceeding the assessment time of 4 s to prevent intraoperative complications. We designed an intraoperative language paradigm by combining classical picture naming and verb generation, which safely engaged highly relevant language functions. (2) Methods-An evaluation study investigated whether a single trial of the language task could be performed in less than 4 s in 30 healthy subjects and whether the suggested language paradigm sufficiently pictured the cortical language network using functional magnetic resonance imaging (fMRI) in 12 healthy subjects. In a feasibility study, 24 brain tumor patients conducted the language task during an awake craniotomy. The patients' neuropsychological outcomes were monitored before and after surgery. (3) Results-The fMRI results in healthy subjects showed activations in a language-associated network around the (left) sylvian fissure. Single language trials could be performed within 4 s. Intraoperatively, all tumor patients showed DCS-induced language errors while conducting the novel language task. Postoperatively, mild neuropsychological impairments appeared compared to the presurgical assessment. (4) Conclusions-These data support the use of a novel language paradigm that safely monitors highly relevant language functions intraoperatively, which can consequently minimize negative postoperative neuropsychological outcomes.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ; intraoperative language mapping; direct cortical stimulation; awake surgery; neuropsychological outcome |
| Subjects: | 100 Philosophy & psychology > 150 Psychology 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurochirurgie Medicine > Lehrstuhl für Neurologie Human Sciences > Institut für Psychologie > Lehrstuhl für Psychologie I (Allgemeine Psychologie I und Methodenlehre) - Prof. Dr. Mark W. Greenlee |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Aug 2022 05:14 |
| Last Modified: | 02 Aug 2022 05:14 |
| URI: | https://pred.uni-regensburg.de/id/eprint/45877 |
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