Hardardottir, Lilja and Bazzano, Maria Victoria and Glau, Laura and Gattinoni, Luca and Koeninger, Angela and Tolosa, Eva and Solano, Maria Emilia (2021) The New Old CD8+T Cells in the Immune Paradox of Pregnancy. FRONTIERS IN IMMUNOLOGY, 12: 765730. ISSN 1664-3224
Full text not available from this repository. (Request a copy)Abstract
CD8+ T cells are the most frequent T cell population in the immune cell compartment at the feto-maternal interface. Due to their cytotoxic potential, the presence of CD8+ T cells in the immune privileged pregnant uterus has raised considerable interest. Here, we review our current understanding of CD8+ T cell biology in the uterus of pregnant women and discuss this knowledge in relation to a recently published immune cell Atlas of human decidua. We describe how the expansion of CD8+ T cells with an effector memory phenotype often presenting markers of exhaustion is critical for a successful pregnancy, and host defense towards pathogens. Moreover, we review new evidence on the presence of long-lasting immunological memory to former pregnancies and discuss its impact on prospective pregnancy outcomes. The formation of fetal-specific memory CD8+ T cell subests in the uterus, in particular of tissue resident, and stem cell memory cells requires further investigation, but promises interesting results to come. Advancing the knowledge of CD8+ T cell biology in the pregnant uterus will be pivotal for understanding not only tissue-specific immune tolerance but also the etiology of complications during pregnancy, thus enabling preventive or therapeutic interventions in the future.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CD8(+) T-CELLS; LEUKOCYTE RECRUITMENT; FETAL TOLERANCE; RESIDENT MEMORY; EXPRESSION; EFFECTOR; RISK; INFECTION; CANCER; PROMOTES; fetal tolerance; feto-maternal interface; decidual CD8+T cells; immune tolerace; Immune regulation; pregnancy; exhaustion |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Geburtshilfe) Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) Medicine > Zentren des Universitätsklinikums Regensburg > Regensburger Centrum für Interventionelle Immunologie (RCI) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 16 Dec 2022 11:43 |
| Last Modified: | 16 Dec 2022 11:43 |
| URI: | https://pred.uni-regensburg.de/id/eprint/45902 |
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