Haimerl, Michael and Utpatel, Kirsten and Goetz, Andrea and Zeman, Florian and Fellner, Claudia and Nickel, Dominik and Luerken, Lukas and Brennfleck, Frank and Stroszczynski, Christian and Scheiter, Alexander and Verloh, Niklas (2021) Quantification of contrast agent uptake in the hepatobiliary phase helps to differentiate hepatocellular carcinoma grade. SCIENTIFIC REPORTS, 11 (1): 22991. ISSN 2045-2322,
Full text not available from this repository. (Request a copy)Abstract
This study aimed to assess the degree of differentiation of hepatocellular carcinoma (HCC) using Gd-EOB-DTPA-assisted magnetic resonance imaging (MRI) with T1 relaxometry. Thirty-three solitary HCC lesions were included in this retrospective study. This study's inclusion criteria were preoperative Gd-EOB-DTPA-assisted MRI of the liver and a histopathological evaluation after hepatic tumor resection. T1 maps of the liver were evaluated to determine the T1 relaxation time and reduction rate between the native phase and hepatobiliary phase (HBP) in liver lesions. These findings were correlated with the histopathologically determined degree of HCC differentiation (G1, well-differentiated; G2, moderately differentiated; G3, poorly differentiated). There was no significant difference between well-differentiated (950.2 +/- 140.2 ms) and moderately/poorly differentiated (1009.4 +/- 202.0 ms) HCCs in the native T1 maps. After contrast medium administration, a significant difference (p <= 0.001) in the mean T1 relaxation time in the HBP was found between well-differentiated (555.4 +/- 140.2 ms) and moderately/poorly differentiated (750.9 +/- 146.4 ms) HCCs. For well-differentiated HCCs, the reduction rate in the T1 time was significantly higher at 0.40 +/- 0.15 than for moderately/poorly differentiated HCCs (0.25 +/- 0.07; p = 0.006). In conclusion this study suggests that the uptake of Gd-EOB-DTPA in HCCs is correlated with tumor grade. Thus, Gd-EOB-DTPA-assisted T1 relaxometry can help to further differentiation of HCC.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GD-EOB-DTPA; FOCAL LIVER-LESIONS; ORGANIC ANION TRANSPORTER; HISTOPATHOLOGIC FINDINGS; HISTOLOGICAL GRADE; HEPATIC-UPTAKE; NEEDLE-BIOPSY; SPIRAL CT; TRANSPLANTATION; ENHANCEMENT; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie Medicine > Lehrstuhl für Pathologie Medicine > Lehrstuhl für Röntgendiagnostik Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Klinische Studien |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 19 Jul 2022 13:59 |
| Last Modified: | 19 Jul 2022 13:59 |
| URI: | https://pred.uni-regensburg.de/id/eprint/45921 |
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