Peschel, Georg and Grimm, Jonathan and Buechler, Christa and Gunckel, Manuela and Pollinger, Kirstin and Aschenbrenner, Elisabeth and Kammerer, Sylvia and Jung, Ernst-Michael and Haimerl, Michael and Werner, Jens and Mueller, Martina and Weigand, Kilian (2021) Liver stiffness assessed by shear-wave elastography declines in parallel with immunoregulatory proteins in patients with chronic HCV infection during DAA therapy. CLINICAL HEMORHEOLOGY AND MICROCIRCULATION, 79 (4). pp. 541-555. ISSN 1386-0291, 1875-8622
Full text not available from this repository. (Request a copy)Abstract
BACKGROUND: A rapid decline of liver stiffness (LS) was detected by non-invasive methods in patients with chronic hepatitis C (HCV) infection during treatment with direct-acting antivirals (DAA). OBJECTIVE: To investigate the influence of inflammation on LS. METHODS: We prospectively examined LS by sonographic shear-wave elastography in 217 patients during DAA therapy from treatment initiation (BL) to 12 weeks after end of therapy (SVR12). Demographic data, laboratory findings and serum levels of cytokines were determined. RESULTS: Values of LS decreased from 1.86 m/s to 1.68 m/s (p = 0.01) which was most pronounced in patients who had F4 fibrosis at BL (3.27 m/s to 2.37 m/s; p < 0.001). Initially elevated values of aminotransferases, ferritin, IgG (p < 0.001 each) and international normalized ratio (p < 0.003) declined, thrombocyte count (p = 0.007) increased. Correlations of these laboratory parameters with BL levels of LS measurement (LSM) were most apparent in patients with F1-F3 fibrosis. Tumor necrosis factor (TNF)-alpha (p = 0.031), interleukin (IL)-10 (p = 0.005) and interferon y inducible protein (IP)-10 (p < 0.001) decreased in parallel with LSM under DAA therapy and corelated with BL values. CONCLUSION: Decrease of systemic inflammatory parameters correlated with LSM under DAA therapy. We conclude that regression of LSM is attributable to the decline of inflammation rather than reflecting fibrosis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SUSTAINED VIROLOGICAL RESPONSE; CHRONIC HEPATITIS-C; CONVENTIONAL ULTRASOUND; TRANSIENT ELASTOGRAPHY; EFSUMB GUIDELINES; ANTIVIRAL THERAPY; CLINICAL-USE; FIBROSIS; VIRUS; RECOMMENDATIONS; HCV; shear-wave elastography; inflammation; fibrosis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Röntgendiagnostik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Aug 2022 05:10 |
| Last Modified: | 22 Aug 2022 05:10 |
| URI: | https://pred.uni-regensburg.de/id/eprint/45923 |
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