Schiltz, Daniel and Mueller, Karolina and Ortner, Christine and Tschernitz, Sebastian and Anker, Alexandra and Felthaus, Oliver and Schreml, Julia and Koller, Michael and Prantl, Lukas and Schreml, Stephan (2021) Multiple Symmetric Lipomatosis: A Cross-Sectional Study to Investigate Clinical Features and Patients' Quality of Life. SYMMETRY-BASEL, 13 (10): 1823. ISSN , 2073-8994
Full text not available from this repository. (Request a copy)Abstract
Within the subcutaneous adipose tissue diseases, multiple symmetric lipomatosis (MSL) (syn.: Launois Bensaude Syndrome, Morbus Madelung, benign symmetric lipomatosis) is rare. The pathogenesis of MSL remains unclear. We investigated the largest German cohort of MSL patients to obtain anamnestic data and quality of life with a standard questionnaire. Twenty-nine patients with confirmed MSL were included and filled in a questionnaire designed for this study. The questionnaire assessed common anamnestic factors, such as quality of life (EQ-5D-3L) and subjective treatment goals and success ( "Patient-Benefit-Index-Lymphedema ", PBI-L). The gender distribution of the patients involved in the study was m/f: 1/4 (male: n = 6 (21%); female n = 23 (79%)). While the exact pathophysiology of MSL remains unclear, a subset of patients' positive family history suggests a strong genetic factor, sometimes compatible with autosomal dominant inheritance. Patients with MSL showed lower health states (EQ VAS Score: m = 51, sd = 24, range = 0-90) than the German norm population (m = 77). Around two thirds (68%) of patients reported relevant benefits of therapy (liposuction/lipectomy). In our cohort about one third of the patients reported a positive family history for MSL-like features. Additionally, at least in some patients, a strong genetic factor, compatible with autosomal dominant inheritance, seems a possible major driver of MSL development. Alcohol consumption and MSL development has to be regarded as a controversial issue. Patients suffering from MSL have a clear decrease in quality of life and a marked wish for treatment.</p>
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LAUNOIS-BENSAUDE; STEM-CELLS; EXPRESSION; DEFECT; multiple symmetric lipomatosis (MSL); Morbus Madelung; Launois Bencaude; benign symmetric lipomatosis (BSL); quality of life in MSL |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Klinische Studien Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Plastische-, Hand- und Wiederherstellungschirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 19 Jul 2022 14:05 |
| Last Modified: | 19 Jul 2022 14:05 |
| URI: | https://pred.uni-regensburg.de/id/eprint/45925 |
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