Proescholdt, Martin A. and Schoedel, Petra and Doenitz, Christian and Pukrop, Tobias and Hoehne, Julius and Schmidt, Nils Ole and Schebesch, Karl-Michael (2021) The Management of Brain Metastases-Systematic Review of Neurosurgical Aspects. CANCERS, 13 (7): 1616. ISSN 2072-6694
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Simple Summary In this comprehensive review, we focused on the neurosurgical treatment as an integrative part of the challenging multidisciplinary management of cerebral metastases, a neuro-oncologic entity, which has been observed to have an increased incidence over the last years. In selected cases, the surgical removal of the space-occupying mass reduces the intracranial pressure, normalizes the metabolic environment, reduces the symptom burden, and allows for the intensification of local and systemic adjuvant treatment. In detail, we discuss the incidence of brain metastases, the role of surgical resection, as well as the evolution of current neurosurgical techniques, the surgical morbidity and mortality of single and multiple lesions, and we enlighten the role of surgery for recurrent tumors. The multidisciplinary management of patients with brain metastases (BM) consists of surgical resection, different radiation treatment modalities, cytotoxic chemotherapy, and targeted molecular treatment. This review presents the current state of neurosurgical technology applied to achieve maximal resection with minimal morbidity as a treatment paradigm in patients with BM. In addition, we discuss the contribution of neurosurgical resection on functional outcome, advanced systemic treatment strategies, and enhanced understanding of the tumor biology.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | STEREOTACTIC RADIOSURGERY SRS; INTERSTITIAL THERMAL THERAPY; SURGICAL RESECTION; CEREBRAL METASTASES; FLUORESCEIN SODIUM; PROGNOSTIC-FACTORS; BREAST-CANCER; LUNG-CANCER; RETROSPECTIVE ANALYSIS; SINGLE METASTASES; brain metastases; surgical resection; infiltration; neuronavigation; fluorescence-guided surgery |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) Medicine > Lehrstuhl für Neurochirurgie Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 16 Dec 2022 11:46 |
| Last Modified: | 16 Dec 2022 11:46 |
| URI: | https://pred.uni-regensburg.de/id/eprint/45926 |
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