Hauck, Christian and Schober, Andreas and Schober, Alexander and Fredersdorf-Hahn, Sabine and Hubauer, Ute and Keyser, Andreas and Maier, Lars and Jungbauer, Carsten and Uecer, Ekrem (2022) Secondary prevention implantable cardioverter-defibrillator (ICD) therapy: value in octogenarians. AGING CLINICAL AND EXPERIMENTAL RESEARCH, 34. pp. 1073-1080. ISSN 1594-0667, 1720-8319
Full text not available from this repository. (Request a copy)Abstract
Background Implantable cardioverter-defibrillator (ICD) therapy is well established for secondary prevention, but studies on the efficacy and safety in elderly patients are still lacking. This retrospective study compared the outcome after ICD implantation between octogenarians and other age groups. Methods Data were obtained from a local ICD registry. Patients who received ICD implantation for secondary prevention at our department were included. All-cause mortality, appropriate ICD therapy and acute adverse events requiring surgical intervention were compared between different age groups. Results 519 patients were enrolled, 34 of whom were aged >= 80 years. During the median follow-up of 35 months after ICD implantation 129 patients (annual mortality rate 5.0%) had died, including 16 patients aged >= 80 years (annual mortality rate 9.4%). The mortality rate of patients aged >= 80 years was significantly higher than that of patients aged <= 69 years (p < 0.001), but similar to that of patients aged 70-79 years. Age at the time of ICD implantation was an independent predictor of all-cause mortality (p < 0.001). 29.7% of patients had appropriate ICD therapy with no difference between age groups. Acute adverse events leading to surgical intervention were low (n = 13) and not age-related. Conclusion Age is an independent predictor of mortality after ICD implantation for secondary prevention. Mortality rates did not differ significantly between octogenarians and other elderly aged 70-79 years. Appropriate ICD therapy and acute adverse events leading to surgical intervention were not age-related. Implantable cardioverter-defibrillator therapy for secondary prevention seems to be an effective and safe treatment modality in octogenarians.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CARDIAC-RESYNCHRONIZATION THERAPY; ANTIARRHYTHMIC-DRUG THERAPY; 2021 ESC GUIDELINES; ELDERLY-PATIENTS; SURVIVAL; LIFE; Implantable cardioverter defibrillator; Elderly; Octogenarians; Secondary prevention; Mortality |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Herz-, Thorax- und herznahe Gefäßchirurgie Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Petra Gürster |
| Date Deposited: | 15 May 2024 08:06 |
| Last Modified: | 15 May 2024 08:06 |
| URI: | https://pred.uni-regensburg.de/id/eprint/45933 |
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