Schroeder, Agnes and Gubernator, Joshua and Leikam, Alexandra and Nazet, Ute and Cieplik, Fabian and Jantsch, Jonathan and Neubert, Patrick and Titze, Jens and Proff, Peter and Kirschneck, Christian (2021) Dietary Salt Accelerates Orthodontic Tooth Movement by Increased Osteoclast Activity. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22 (2): 596. ISSN , 1422-0067
Full text not available from this repository. (Request a copy)Abstract
Dietary salt uptake and inflammation promote sodium accumulation in tissues, thereby modulating cells like macrophages and fibroblasts. Previous studies showed salt effects on periodontal ligament fibroblasts and on bone metabolism by expression of nuclear factor of activated T-cells-5 (NFAT-5). Here, we investigated the impact of salt and NFAT-5 on osteoclast activity and orthodontic tooth movement (OTM). After treatment of osteoclasts without (NS) or with additional salt (HS), we analyzed gene expression and the release of tartrate-resistant acid phosphatase and calcium phosphate resorption. We kept wild-type mice and mice lacking NFAT-5 in myeloid cells either on a low, normal or high salt diet and inserted an elastic band between the first and second molar to induce OTM. We analyzed the expression of genes involved in bone metabolism, periodontal bone loss, OTM and bone density. Osteoclast activity was increased upon HS treatment. HS promoted periodontal bone loss and OTM and was associated with reduced bone density. Deletion of NFAT-5 led to increased osteoclast activity with NS, whereas we detected impaired OTM in mice. Dietary salt uptake seems to accelerate OTM and induce periodontal bone loss due to reduced bone density, which may be attributed to enhanced osteoclast activity. NFAT-5 influences this reaction to HS, as we detected impaired OTM and osteoclast activity upon deletion.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ; salt; orthodontic tooth movement; osteoclast activity |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Kieferorthopädie Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene Medicine > Lehrstuhl für Zahnerhaltung und Parodontologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Aug 2022 05:37 |
| Last Modified: | 02 Aug 2022 05:37 |
| URI: | https://pred.uni-regensburg.de/id/eprint/45935 |
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