Galler, Kerstin M. and Gratz, Eva-Maria and Widbiller, Matthias and Buchalla, Wolfgang and Knuttel, Helge (2021) Pathophysiological mechanisms of root resorption after dental trauma: a systematic scoping review. BMC ORAL HEALTH, 21 (1): 163. ISSN 1472-6831,
Full text not available from this repository. (Request a copy)Abstract
Background The objective of this scoping review was to systematically explore the current knowledge of cellular and molecular processes that drive and control trauma-associated root resorption, to identify research gaps and to provide a basis for improved prevention and therapy. Methods Four major bibliographic databases were searched according to the research question up to February 2021 and supplemented manually. Reports on physiologic, histologic, anatomic and clinical aspects of root resorption following dental trauma were included. Duplicates were removed, the collected material was screened by title/abstract and assessed for eligibility based on the full text. Relevant aspects were extracted, organized and summarized. Results 846 papers were identified as relevant for a qualitative summary. Consideration of pathophysiological mechanisms concerning trauma-related root resorption in the literature is sparse. Whereas some forms of resorption have been explored thoroughly, the etiology of others, particularly invasive cervical resorption, is still under debate, resulting in inadequate diagnostics and heterogeneous clinical recommendations. Effective therapies for progressive replacement resorptions have not been established. Whereas the discovery of the RANKL/RANK/OPG system is essential to our understanding of resorptive processes, many questions regarding the functional regulation of osteo-/odontoclasts remain unanswered. Conclusions This scoping review provides an overview of existing evidence, but also identifies knowledge gaps that need to be addressed by continued laboratory and clinical research.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PERIODONTAL-LIGAMENT CELLS; KAPPA-B LIGAND; EXTERNAL CERVICAL RESORPTION; COLONY-STIMULATING FACTOR; OSTEOCLAST DIFFERENTIATION FACTOR; AVULSED PERMANENT INCISORS; NECROSIS-FACTOR RECEPTOR; HORMONE-RELATED PROTEIN; HUMAN DECIDUOUS TEETH; BONE-RESORPTION; Root resorption; Tooth resorption; Osteoclast; Receptor activator of nuclear factor-kappa B; RANK ligand; Osteoprotegerin |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Zahnerhaltung und Parodontologie Central Institutions > University Library |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Aug 2022 10:01 |
| Last Modified: | 02 Aug 2022 10:01 |
| URI: | https://pred.uni-regensburg.de/id/eprint/46001 |
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