Perju, Antonia and Wongkaew, Nongnoot (2021) Integrating high-performing electrochemical transducers in lateral flow assay. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 413 (22). pp. 5535-5549. ISSN 1618-2642, 1618-2650
Full text not available from this repository. (Request a copy)Abstract
Lateral flow assays (LFAs) are the best-performing and best-known point-of-care tests worldwide. Over the last decade, they have experienced an increasing interest by researchers towards improving their analytical performance while maintaining their robust assay platform. Commercially, visual and optical detection strategies dominate, but it is especially the research on integrating electrochemical (EC) approaches that may have a chance to significantly improve an LFA's performance that is needed in order to detect analytes reliably at lower concentrations than currently possible. In fact, EC-LFAs offer advantages in terms of quantitative determination, low-cost, high sensitivity, and even simple, label-free strategies. Here, the various configurations of EC-LFAs published are summarized and critically evaluated. In short, most of them rely on applying conventional transducers, e.g., screen-printed electrode, to ensure reliability of the assay, and additional advances are afforded by the beneficial features of nanomaterials. It is predicted that these will be further implemented in EC-LFAs as high-performance transducers. Considering the low cost of point-of-care devices, it becomes even more important to also identify strategies that efficiently integrate nanomaterials into EC-LFAs in a high-throughput manner while maintaining their favorable analytical performance.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LABEL-FREE DETECTION; IMMUNOCHROMATOGRAPHIC ASSAY; QUANTITATIVE DETECTION; TEST STRIP; SENSITIVE DETECTION; GOLD NANOPARTICLES; IMMUNOSENSOR; BIOSENSOR; QUANTIFICATION; POINT; Lateral flow assay; Electrochemical detection; Point-of-care devices; Electrochemical transducers; Nanofibers |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Analytische Chemie, Chemo- und Biosensorik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 Jul 2022 09:40 |
| Last Modified: | 05 Jul 2022 09:40 |
| URI: | https://pred.uni-regensburg.de/id/eprint/46025 |
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