Song, Christina and Lee, Jacob S. and Gilfillan, Susan and Robinette, Michelle L. and Newberry, Rodney D. and Stappenbeck, Thaddeus S. and Mack, Matthias and Cella, Marina and Colonna, Marco (2015) Unique and redundant functions of NKp46(+) ILC3s in models of intestinal inflammation. JOURNAL OF EXPERIMENTAL MEDICINE, 212 (11). pp. 1869-1882. ISSN 0022-1007, 1540-9538
Full text not available from this repository. (Request a copy)Abstract
Group 3 ILCs (ILC3s) are innate sources of IL-22 and IL-17 and include lymphoid tissue-inducer (LTi)-like and NKp46(+) subsets. Both depend on ROR gamma t and aryl hydrocarbon receptor, but NKp46(+) ILC3s also require Notch and T-bet for their development and are transcriptionally distinct. The extent to which these subsets have unique functions, especially in the context of T cell-and B cell-sufficient mice, remains largely unclear. To investigate the specific function of NKp46(+) ILC3s among other ILC3 subsets and T cells, we generated mice selectively lacking NKp46(+) ILC3s or all ILC3s and crossed them to T cell-deficient mice, thus maintaining B cells in all mice. In mice lacking T cells, NKp46(+) ILC3s were sufficient to promote inflammatory monocyte accumulation in the anti-CD40 innate colitis model through marked production of GM-CSF. In T cell-competent mice, lack of NKp46(+) ILCs had no impact on control of intestinal C. rodentium infection, whereas lack of all ILC3s partially impaired bacterial control. Thus, NKp46(+) ILC3s have a unique capacity to promote inflammation through GM-CSF-induced accumulation of inflammatory monocytes, but are superseded by LTi-like ILC3s and T cells in controlling intestinal bacterial infection.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INNATE LYMPHOID-CELLS; EFFACING BACTERIAL PATHOGENS; COMMENSAL BACTERIA; T-CELLS; HOST-DEFENSE; RECEPTOR; INTERLEUKIN-22; PATHOLOGY; LYMPHOCYTES; PROTECTION; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Nephrologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 May 2019 12:00 |
| Last Modified: | 13 May 2019 12:00 |
| URI: | https://pred.uni-regensburg.de/id/eprint/4608 |
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