Verloh, Niklas and Utpatel, Kirsten and Haimerl, Michael and Zeman, Florian and Fellner, Claudia and Fichtner-Feigl, Stefan and Teufel, Andreas and Stroszczynski, Christian and Evert, Matthias and Wiggermann, Philipp (2015) Liver fibrosis and Gd-EOB-DTPA-enhanced MRI: A histopathologic correlation. SCIENTIFIC REPORTS, 5: 15408. ISSN 2045-2322,
Full text not available from this repository. (Request a copy)Abstract
Gadolinium ethoxybenzyl-diethylenetriaminepentaacetic acid (Gd-EOB-DTPA) is a hepatocyte-specific MRI contrast agent. Because the hepatic uptake of Gd-EOB-DTPA depends on the integrity of the hepatocyte mass, this uptake can be quantified to assess liver function. We report the relationship between the extent of Gd-EOB-DTPA uptake and the degree of liver fibrosis. T1-weighted volume-interpolated breath-hold examination (VIBE) sequences with fat suppression were acquired before and 20 minutes after contrast injection. Strong correlations of the uptake characteristics of Gd-EOB-DTPA with the relative enhancement (RE) of the liver parenchyma and the grade of fibrosis/cirrhosis, classified using the Ishak scoring system, were observed. The subdivisions between the grades of liver fibrosis based on RE were highly significant for all combinations, and a ROC revealed sensitivities >= 82% and specificities >= 87% for all combinations. MR imaging is a satisfactorily sensitive method for the assessment of liver fibrosis/cirrhosis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CONTRAST AGENT; HEPATOBILIARY-PHASE; HEPATIC-UPTAKE; HEPATOCELLULAR-CARCINOMA; MOLECULAR-MECHANISMS; GADOXETATE DISODIUM; GADOLINIUM CHELATE; SIGNAL INTENSITY; 3 TESLA; CIRRHOSIS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Röntgendiagnostik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 May 2019 12:04 |
| Last Modified: | 13 May 2019 12:04 |
| URI: | https://pred.uni-regensburg.de/id/eprint/4609 |
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