Hegner, Philipp and Lebek, Simon and Tafelmeier, Maria and Camboni, Daniele and Schopka, Simon and Schmid, Christof and Maier, Lars Siegfried and Arzt, Michael and Wagner, Stefan (2021) Sleep-disordered breathing is independently associated with reduced atrial connexin 43 expression. HEART RHYTHM, 18 (12). pp. 2187-2194. ISSN 1547-5271, 1556-3871
Full text not available from this repository. (Request a copy)Abstract
BACKGROUND Patients with atrial fibrillation (AF) exhibit decreased atrial expression of connexin (Cx), which has been causally linked to a proarrhythmogenic substrate. Interestingly, patients with sleep-disordered breathing (SDB) are at increased risk of AF, but the mechanisms remain unclear. OBJECTIVE We tested the hypothesis that patients with SDB have reduced atrial Cx expression independent of important comorbidities. METHODS We analyzed right atrial appendage biopsies from 77 patients undergoing coronary artery bypass grafting. Patients were tested for SDB by polygraphy before surgery. Expression of Cx40 and Cx43 messenger RNA was quantified using real-time quantitative polymerase chain reaction and Western blot (Cx43). Structural atrial remodeling was investigated histologically and by quantitative polymerase chain reaction. Postoperative AF was assessed by 12-lead electrocardiography. RESULTS Patients were stratified according to apnea-hypopnea index (SDB if apnea-hypopnea index similar to 15 per hour, n=32 vs n=45). Patients with SDB had significantly lower atrial Cx43 expression, which was negatively correlated with apnea-hypopnea index and oxygen desaturation index. No significant increase in atrial fibrosis or expression of hypertrophy and inflammatory markers was observed. Interestingly, SDB remained the strongest independent predictor of decreased atrial Cx43 expression in a multivariate logistic regression model including age, sex, diabetes, and heart failure with reduced ejection fraction (odds ratio 7.58; 95% confidence interval 1.891-30.375; P = .004). Moreover, reduced atrial Cx43 expression was strongly associated with the occurrence of postoperative AF (odds ratio 15.749; 95% confidence interval 1.0722-31.472; P = .044). CONCLUSION Patients with SDB exhibited decreased atrial Cx43 expression, which correlated with the severity of SDB. This correlation was independent of several concomitant diseases and may be linked to an increased risk of AF after cardiac surgery.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GAP-JUNCTIONS; FIBRILLATION; APNEA; CONDUCTION; HEART; MYOCARDIUM; MECHANISMS; SUBSTRATE; PRESSURE; Atrial connexin expression; Atrial conduction; Atrial fibrillation; Connexin 43; Sleep apnea |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Herz-, Thorax- und herznahe Gefäßchirurgie Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 Aug 2022 09:36 |
| Last Modified: | 08 Aug 2022 09:36 |
| URI: | https://pred.uni-regensburg.de/id/eprint/46129 |
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