Neurobiology of the lateral septum: regulation of social behavior

Menon, Rohit and Suss, Theresa and Oliveira, Vinicius Elias de Moura and Neumann, Inga D. and Bludau, Anna (2022) Neurobiology of the lateral septum: regulation of social behavior. TRENDS IN NEUROSCIENCES, 45 (1). pp. 27-40. ISSN 0166-2236, 1878-108X

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Abstract

Social interactions are essential for mammalian life and are regulated by evolutionary conserved neuronal mechanisms. An individual's internal state, experiences, and the nature of the social stimulus are critical for determining apt responses to social situations. The lateral septum (LS) - a structure of the basal forebrain - integrates abundant cortical and subcortical inputs, and projects to multiple downstream regions to generate appropriate behavioral responses. Although incoming cognitive information is indispensable for contextualizing a social stimulus, neuromodulatory information related to the internal state of the organism significantly influences the behavioral outcome as well. This review article provides an overview of the neuroanatomical properties of the LS, and examines its neurochemical (neuropeptidergic and hormonal) signaling, which provide the neuromodulatory information essential for fine-tuning social behavior across the lifespan.

Item Type: Article
Uncontrolled Keywords: SEX-SPECIFIC REGULATION; MATERNAL AGGRESSION; OXYTOCIN RECEPTOR; VASOPRESSIN RECEPTOR; INTERMALE AGGRESSION; HIPPOCAMPAL CA2; PREOPTIC AREA; BRAIN; NEURONS; STRESS
Subjects: 500 Science > 590 Zoological sciences
600 Technology > 610 Medical sciences Medicine
Divisions: Biology, Preclinical Medicine > Institut für Zoologie > Tierphysiologie/Neurobiologie (Prof. Dr. Inga Neumann)
Depositing User: Petra Gürster
Date Deposited: 29 Nov 2022 05:52
Last Modified: 29 Nov 2022 05:52
URI: https://pred.uni-regensburg.de/id/eprint/46131

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