Vogel, Manuel J. and Mustroph, Julian and Staudner, Stephan T. and Leininger, Simon B. and Hubauer, Ute and Wallner, Stefan and Meindl, Christine and Hanses, Frank and Zimmermann, Markus and Maier, Lars S. and Jungbauer, Carsten G. and Hupf, Julian (2021) Kidney injury molecule-1: potential biomarker of acute kidney injury and disease severity in patients with COVID-19. JOURNAL OF NEPHROLOGY, 34 (4). pp. 1007-1018. ISSN 1121-8428, 1724-6059
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Aims The aim of the current study was to evaluate whether tubular markers kidney injury molecule-1 (KIM-1) and N-acetyl-beta-glucosaminidase (NAG) are related to acute kidney injury (AKI) and severe disease in patients with COVID-19. Methods and results In this prospective observational clinical trial we examined a cohort of 80 patients with proof of acute respiratory infection and divided them into a COVID-19 cohort (n = 54) and a control cohort (n = 26). KIM-1 and NAG were measured from urine samples collected in the emergency department. We assessed the development of AKI, admission to the intensive care unit (ICU) and intrahospital death as clinical endpoints. Urinary KIM-1 and NAG were not significantly different between patients with SARS-CoV-2 and those with other respiratory infections (each p = n.s.). Eight patients from the COVID-19 cohort and five of the non-COVID-19-patients suffered from acute kidney injury during their stay. Nine COVID-19 patients and two non-COVID-19 patients were admitted to the ICU. KIM-1 was significantly elevated in COVID-19 patients with, compared to those without AKI (p = 0.005), as opposed to NAG and creatinine (each p = n.s.). Furthermore, KIM-1 was significantly elevated in the patients with COVID-19 that had to be transferred to the ICU (p =0.015), in contrast to NAG and creatinine (each p = n.s.). Conclusion Assessing KIM-1 in patients with COVID-19 might provide additional value in recognizing AKI at an early stage of disease. Further, KIM-1 might indicate higher risk for clinical deterioration as displayed by admission to the ICU. [GRAPHICS] .
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DIAGNOSIS; RECEPTOR; FAILURE; EVENTS; NUMBER; KIM-1; ACE2; KIM-1; COVID-19; NAG; Acute kidney injury |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Innere Medizin II Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin Medicine > Notfallambulanz |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 Aug 2022 08:12 |
| Last Modified: | 09 Aug 2022 08:12 |
| URI: | https://pred.uni-regensburg.de/id/eprint/46184 |
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