Niedermaier, Tobias and Behrens, Gundula and Schmid, Daniela and Schlecht, Inga and Fischer, Beate and Leitzmann, Michael F. (2015) Body mass index, physical activity, and risk of adult meningioma and glioma A meta-analysis. NEUROLOGY, 85 (15). pp. 1342-1350. ISSN 0028-3878, 1526-632X
Full text not available from this repository. (Request a copy)Abstract
Objective:Whether adiposity and lack of physical activity affect the risk for developing meningioma and glioma is poorly understood. Our objective was to characterize these associations in detail.Methods:We conducted a systematic review and meta-analysis of adiposity and physical activity in relation to meningioma and glioma using cohort and case-control studies published through February 2015. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.Results:We identified 12 eligible studies of body mass index (BMI) and 6 studies of physical activity, comprising up to 2,982 meningioma cases and 3,057 glioma cases. Using normal weight as the reference group, overweight (summary relative risk [RR] = 1.21, 95% confidence interval [CI] = 1.01-1.43) and obesity (RR = 1.54, 95% CI = 1.32-1.79) were associated with increased risk of meningioma. In contrast, overweight (RR = 1.06, 95% CI = 0.94-1.20) and obesity (RR = 1.11, 95% CI = 0.98-1.27) were unrelated to glioma. Similarly, dose-response meta-analyses revealed a statistically significant positive association of BMI with meningioma, but not glioma. High vs low physical activity levels showed a modest inverse relation to meningioma (RR = 0.73, 95% CI = 0.61-0.88) and a weak inverse association with glioma (RR = 0.86, 95% CI = 0.76-0.97). Relations persisted when the data were restricted to prospective studies, except for the association between physical activity and glioma, which was rendered statistically nonsignificant (RR = 0.91, 95% CI = 0.77-1.07).Conclusions:Adiposity is related to enhanced risk for meningioma but is unassociated with risk for glioma. Based on a limited body of evidence, physical activity is related to decreased risk of meningioma but shows little association with risk of glioma.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GROWTH-FACTOR-I; BRAIN-TUMORS; INTRACRANIAL MENINGIOMA; GENE POLYMORPHISMS; OXIDATIVE STRESS; INSULIN; WEIGHT; WOMEN; EPIDEMIOLOGY; EXPOSURES; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin |
| Depositing User: | Petra Gürster |
| Date Deposited: | 26 Aug 2020 08:25 |
| Last Modified: | 26 Aug 2020 08:25 |
| URI: | https://pred.uni-regensburg.de/id/eprint/4621 |
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