Bauer, Susanne and Strack, Christina and Uecer, Ekrem and Wallner, Stefan and Hubauer, Ute and Luchner, Andreas and Maier, Lars Siegfried and Jungbauer, Carsten (2021) Evaluation of a multimarker panel in chronic heart failure: a 10-year follow-up. BIOMARKERS IN MEDICINE, 15 (18). pp. 1709-1719. ISSN 1752-0363, 1752-0371
Full text not available from this repository. (Request a copy)Abstract
Aim: We assessed the 10-year prognostic role of 11 biomarkers with different pathophysiological backgrounds. Materials & methods/results: Blood samples from 144 patients with heart failure were analyzed. After 10 years of follow-up (median follow-up was 104 months), data regarding all-cause mortality were acquired. Regarding Kaplan-Meier analysis, all markers, except TIMP-1 and GDF-15, were significant predictors for all-cause mortality. We created a multimarker model with nt-proBNP, hsTnT and IGF-BP7 and found that patients in whom all three markers were elevated had a significantly worse long-time-prognosis than patients without elevated markers. Conclusion: In a 10-year follow-up, a combination of three biomarkers (NT-proBNP, hs-TnT, IGF-BP7) identified patients with a high risk of mortality.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FACTOR-BINDING PROTEIN-7; GROWTH-DIFFERENTIATION FACTOR-15; SENSITIVE TROPONIN-T; EJECTION FRACTION; TISSUE INHIBITOR; NT-PROBNP; ASSOCIATION; BIOMARKERS; PROGNOSIS; METALLOPROTEINASE-1; heart failure; hs-TnT; IGF-BP7; multimarker panel; NT-proBNP; prognostication |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 Aug 2022 13:35 |
| Last Modified: | 09 Aug 2022 13:35 |
| URI: | https://pred.uni-regensburg.de/id/eprint/46247 |
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