Kerschbaum, Maximilian and Lang, Siegmund and Henssler, Leopold and Ernstberger, Antonio and Alt, Volker and Pfeifer, Christian and Worlicek, Michael and Popp, Daniel (2021) Influence of Oral Anticoagulation and Antiplatelet Drugs on Outcome of Elderly Severely Injured Patients. JOURNAL OF CLINICAL MEDICINE, 10 (8): 1649. ISSN , 2077-0383
Full text not available from this repository. (Request a copy)Abstract
Introduction: Severely injured elderly patients have a poorer prognosis and higher mortality rates after severe trauma compared with younger patients. The aim of this study was to correlate the influence of pre-existing oral anticoagulation (OAC) and antiplatelet drugs (PAI) on the outcome of severely injured elderly patients. Methods: Using a prospective cohort study model over an 11-year period, severely injured elderly patients (>= 65 years and ISS >= 16) were divided into two groups (no anticoagulation/platelet inhibitors: nAP and OAC/PAI). A comparison of the groups was conducted regarding injury frequency, trauma mechanism, severity of head injuries, and medication-related mortality. Results: In total, 254 out of 301 patients were analyzed (nAP: n = 145; OAC/PAI: n = 109, unknown data: n = 47). The most relevant injury was falling from low heights (<3 m), which led to a significantly higher number of severe injuries in patients with OAC/PAI. Patients with pre-existing OAC/PAI showed a significantly higher overall mortality rate compared to the group without (38.5% vs. 24.8%; p = 0.019). The severity of head injuries in OAC/PAI was also higher on average (AIS 3.7 +/- 1.6 vs. 2.8 +/- 1.9; p = 0.000). Conclusion: Pre-existing oral anticoagulation and/or platelet aggregation inhibitors are related to a higher mortality rate in elderly polytrauma patients. Low-energy trauma can lead to even more severe head injuries due to pre-existing medication than is already the case in elderly patients without OAC/PAI.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ; elderly polytrauma; anticoagulation; mortality |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Unfallchirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 23 Aug 2022 13:11 |
| Last Modified: | 23 Aug 2022 13:11 |
| URI: | https://pred.uni-regensburg.de/id/eprint/46355 |
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