Baier, Maria J. and Noack, Jannis and Seitz, Mark Tilmann and Maier, Lars S. and Neef, Stefan (2021) Phosphorylation of RyR2 Ser-2814 by CaMKII mediates beta 1-adrenergic stress induced Ca2+-leak from the sarcoplasmic reticulum. FEBS OPEN BIO, 11 (10). pp. 2756-2762. ISSN 2211-5463,
Full text not available from this repository. (Request a copy)Abstract
Adrenergic stimulation, while being the central mechanism of cardiac positive inotropy, is a universally acknowledged inductor of undesirable sarcoplasmic reticulum (SR) Ca2+ leak. However, the exact mechanisms for this remained unspecified so far. This study shows that Ca2+/calmodulin-dependent protein kinase II (CaMKII)-specific phosphorylation of ryanodine receptor type 2 at Ser-2814 is the pivotal mechanism by which SR Ca2+ leak develops downstream of beta 1-adrenergic stress by increase of the leak/load relationship. Cardiomyocytes with a Ser-2814 phosphoresistant mutation (S2814A) were protected from isoproterenol-induced SR Ca2+ leak and consequently displayed improved postrest potentiation of systolic Ca2+ release under adrenergic stress compared to littermate wild-type cells.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PROTEIN-KINASE-II; SR CA2+ LEAK; RYANODINE RECEPTOR; CALCIUM LEAK; HEART; adrenergic stress; CaMKII; RyR2; Ser-2814; SR Ca2+ leak |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 24 Aug 2022 06:02 |
| Last Modified: | 24 Aug 2022 06:02 |
| URI: | https://pred.uni-regensburg.de/id/eprint/46357 |
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