Rathberger, Katharina and Haeusler, Sebastian and Wellmann, Sven and Weigl, Marco and Langhammer, Florian and Bazzano, Maria Victoria and Ambrosch, Andreas and Malfertheiner, Sara Fill (2021) SARS-CoV-2 in pregnancy and possible transfer of immunity: assessment of peripartal maternal and neonatal antibody levels and a longitudinal follow-up. JOURNAL OF PERINATAL MEDICINE, 49 (6). pp. 702-708. ISSN 0300-5577, 1619-3997
Full text not available from this repository. (Request a copy)Abstract
Objectives: In the current Severe Acute Respiratory Distress Coronavirus 2 (SARS-CoV-2) pandemic there is still great uncertainty about the effects of an infection in pregnancy especially regarding a possible fetal transmission of antibodies to SARS-CoV-2 and the longevity of this immunity. Methods: Sixteen women who were infected with SARS-CoV-2 during pregnancy and their offspring were included. The antibody response to SARS-CoV-2 was measured in mother and umbilical cord blood peripartum and in a follow-up examination 6-11 weeks after birth. Medical history, symptoms regarding SARS-CoV-2, obstetric and neonatal information were queried following recommendations by the WHO. Results: A total of 73% of the women and one third of the infants developed antibodies to SARS-CoV-2 spike (S) protein receptor binding domain (RBD), with a long interval between infection and birth proving favorable for a transplacentar transfer of antibodies to the neonates. All infants showed declining or vanishing antibody-titers in the follow-up examination, while the titers of their mothers were stable or even increased. Conclusions: Our results demonstrate that transplacental transfer of SARS-CoV-2-specific antibodies is possible, but also indicate that the immunity that may be gained as a result might decrease in newborns postpartum. This provides important evidence that could be useful for further studies covering vaccination during pregnancy.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | WOMEN; IgA; IgG; immunity; peripartum period; pregnancy; SARS-CoV-2; screening |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Geburtshilfe) Medicine > Lehrstuhl für Kinder- und Jugendmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 24 Aug 2022 12:25 |
| Last Modified: | 24 Aug 2022 12:25 |
| URI: | https://pred.uni-regensburg.de/id/eprint/46366 |
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