Oliveira, Vinicius Elias de Moura and Lukas, Michael and Wolf, Hannah Nora and Durante, Elisa and Lorenz, Alexandra and Mayer, Anna-Lena and Bludau, Anna and Bosch, Oliver J. and Grinevich, Valery and Egger, Veronica and de Jong, Trynke R. and Neumann, Inga D. (2021) Oxytocin and vasopressin within the ventral and dorsal lateral septum modulate aggression in female rats. NATURE COMMUNICATIONS, 12 (1): 2900. ISSN 2041-1723,
Full text not available from this repository. (Request a copy)Abstract
In contrast to male rats, aggression in virgin female rats has been rarely studied. Here, we established a rat model of enhanced aggression in females using a combination of social isolation and aggression-training to specifically investigate the involvement of the oxytocin (OXT) and arginine vasopressin (AVP) systems within the lateral septum (LS). Using neuropharmacological, optogenetic, chemogenetic as well as microdialysis approaches, we revealed that enhanced OXT release within the ventral LS (vLS), combined with reduced AVP release within the dorsal LS (dLS), is required for aggression in female rats. Accordingly, increased activity of putative OXT receptor-positive neurons in the vLS, and decreased activity of putative AVP receptor-positive neurons in the dLS, are likely to underly aggression in female rats. Finally, in vitro activation of OXT receptors in the vLS increased tonic GABAergic inhibition of dLS neurons. Overall, our data suggest a model showing that septal release of OXT and AVP differentially affects aggression in females by modulating the inhibitory tone within LS sub-networks. Aggression in females is understudied in model organisms. Here, the authors establish a model of enhanced aggression in virgin female rats and show that oxytocin and vasopressin systems differentially modulate aggression in distinct neuronal populations of the lateral septum of female rats.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ARGININE-VASOPRESSIN; SEX-DIFFERENCES; MATERNAL AGGRESSION; CENTRAL AMYGDALA; INTRASPECIFIC AGGRESSION; SOCIAL AVOIDANCE; RECEPTOR-BINDING; BRAIN OXYTOCIN; BEHAVIOR; RELEASE; |
| Subjects: | 500 Science > 590 Zoological sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie > Tierphysiologie/Neurobiologie (Prof. Dr. Inga Neumann) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 29 Aug 2022 08:21 |
| Last Modified: | 29 Aug 2022 08:21 |
| URI: | https://pred.uni-regensburg.de/id/eprint/46422 |
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