Wiest, Reiner and Weiss, Thomas S. and Danielyan, Lusine and Buechler, Christa (2021) Serum Amyloid Beta42 Is Not Eliminated by the Cirrhotic Liver: A Pilot Study. JOURNAL OF CLINICAL MEDICINE, 10 (12): 2669. ISSN , 2077-0383
Full text not available from this repository. (Request a copy)Abstract
Amyloid-beta (A beta) deposition in the brain is the main pathological hallmark of Alzheimer disease. Peripheral clearance of A beta may possibly also lower brain levels. Recent evidence suggested that hepatic clearance of A beta 42 is impaired in liver cirrhosis. To further test this hypothesis, serum A beta 42 was measured by ELISA in portal venous serum (PVS), systemic venous serum (SVS), and hepatic venous serum (HVS) of 20 patients with liver cirrhosis. Mean A beta 42 level was 24.7 +/- 20.4 pg/mL in PVS, 21.2 +/- 16.7 pg/mL in HVS, and 19.2 +/- 11.7 pg/mL in SVS. Similar levels in the three blood compartments suggested that the cirrhotic liver does not clear A beta 42. A beta 42 was neither associated with the model of end-stage liver disease score nor the Child-Pugh score. Patients with abnormal creatinine or bilirubin levels or prolonged prothrombin time did not display higher A beta 42 levels. Patients with massive ascites and patients with large varices had serum A beta 42 levels similar to patients without these complications. Serum A beta 42 was negatively associated with connective tissue growth factor levels (r = -0.580, p = 0.007) and a protective role of A beta 42 in fibrogenesis was already described. Diabetic patients with liver cirrhosis had higher A beta 42 levels (p = 0.069 for PVS, p = 0.047 for HVS and p = 0.181 for SVS), which is in accordance with previous reports. Present analysis showed that the cirrhotic liver does not eliminate A beta 42. Further studies are needed to explore the association of liver cirrhosis, A beta 42 levels, and cognitive dysfunction.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TISSUE GROWTH-FACTOR; C-REACTIVE PROTEIN; PORTAL-HYPERTENSION; ALZHEIMERS-DISEASE; PLASMA A-BETA-40; NITRIC-OXIDE; A-BETA; CLEARANCE; CHEMERIN; DIMETHYLARGININE; portal vein; MELD score; bilirubin; ascites; hepatic clearance; liver cirrhosis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Kinder- und Jugendmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 29 Aug 2022 08:29 |
| Last Modified: | 29 Aug 2022 08:29 |
| URI: | https://pred.uni-regensburg.de/id/eprint/46426 |
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