Karrer, Sigrid and Szeimies, Rolf-Markus and Philipp-Dormston, Wolfgang G. and Gerber, Peter A. and Prager, Welf and Datz, Elisabeth and Zeman, Florian and Mueller, Karolina and Koller, Michael (2021) Repetitive Daylight Photodynamic Therapy versus Cryosurgery for Prevention of Actinic Keratoses in Photodamaged Facial Skin: A Prospective, Randomized Controlled Multicentre Two-armed Study. ACTA DERMATO-VENEREOLOGICA, 101: adv00355. ISSN 0001-5555, 1651-2057
Full text not available from this repository. (Request a copy)Abstract
Actinic keratoses are a chronic condition in ultraviolet-damaged skin, with a risk of progressing to invasive skin cancer. The aim of this study was to investigate the preventive potential of field-directed repetitive daylight photodynamic therapy for actinic keratoses. A randomized trial was performed, including 58 patients with >= 5 actinic keratoses on photodamaged facial skin, who received either 5 full-face sessions of daylight photodynamic therapy within a period of 2 years or lesion-directed cryosurgery. Primary outcome was the mean cumulative number of new actinic keratoses developed between visits 2 and 6 (visit 6 being a follow-up). This outcome was lower after daylight photodynamic therapy (7.7) compared with cryosurgery (10.2), but the difference did not reach significance (-2.5, 95% confidence interval -6.2 to 1.2; p=0.18). Several signs of photoageing (fine lines, pigmentation, roughness, erythema, sebaceous gland hyperplasia) were significantly reduced after daylight photodynamic therapy, but not after cryosurgery. Significantly less pain and fewer side-effects were reported during daylight photodynamic therapy than during cryosurgery. This study found that repetitive daylight photodynamic therapy had photo-rejuvenating effects. However, the prevention of actinic keratoses by this therapy could not be proven in a statistically reliable manner.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TOPICAL METHYL AMINOLEVULINATE; EUROPEAN DERMATOLOGY FORUM; TRANSPLANT RECIPIENTS; FIELD; CRYOTHERAPY; STRATEGIES; GUIDELINES; PLACEBO; LESIONS; LIGHT; actinic keratoses; daylight photodynamic therapy; methyl aminolevulinate; photo-rejuvenation; skin cancer prevention; skin ageing |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Klinische Studien |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 29 Aug 2022 12:32 |
| Last Modified: | 29 Aug 2022 12:32 |
| URI: | https://pred.uni-regensburg.de/id/eprint/46455 |
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