Mehringer, Johannes and Hofmann, Evamaria and Touraud, Didier and Koltzenburg, Sebastian and Kellermeier, Matthias and Kunz, Werner (2021) Salting-in and salting-out effects of short amphiphilic molecules: a balance between specific ion effects and hydrophobicity. PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 23 (2). pp. 1381-1391. ISSN 1463-9076, 1463-9084
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Amphiphilic molecules (e.g. hydrotropes) that enhance the solubility of hydrophobic compounds in water are often charged. As a result, such compounds also show specific ion effects. These effects can either strengthen or weaken the solubilisation power of amphiphilic molecules, depending on their degree of ion hydration. They can even prevail and transform an apparent solubilizer into an "anti-hydrotrope", i.e. a salting-out agent. In the present paper, we discuss this subtle balance between specific (Hofmeister) effects exerted by ionic headgroups and the hydrophobicity of the residual compound structure, including the size of the molecule and the presence of electron-withdrawing groups.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HOFMEISTER SERIES; CHARGED HEADGROUPS; PROTEIN STABILITY; WATER; SURFACTANT; RETENTION; BEHAVIOR; ANIONS |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Physikalische und Theoretische Chemie > Chair of Chemistry VI - Physical Chemistry (Solution Chemistry) > Prof. Dr. Werner Kunz |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 10 Aug 2022 11:42 |
| Last Modified: | 10 Aug 2022 11:42 |
| URI: | https://pred.uni-regensburg.de/id/eprint/46469 |
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